Brain-derived neurotrophic factor serum levels in cocaine-dependent patients during early abstinence |
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| Authors: | Margarida Corominas-Roso Carlos Roncero Francisco Jose Eiroa-Orosa Begoña Gonzalvo Lara Grau-Lopez Marta Ribases Laia Rodriguez-Cintas Cristina Sánchez-Mora Josep-Antoni Ramos-Quiroga Miguel Casas |
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| Institution: | 1. Department of Psychiatry, Minneapolis VA Health Care System, Minneapolis, MN 55417, USA;2. Department of Psychiatry, University of Minnesota-Medical School, Minneapolis, MN, USA;3. Department of Medicine, Minneapolis VA Health Care System, Minneapolis, MN 55417, USA;4. Department of Medicine, University of Minnesota-Medical School, Minneapolis, MN, USA;1. National Drug and Alcohol Research Centre, University of New South Wales, Sydney NSW 2052, Australia;2. NHMRC Centre of Research Excellence in Mental Health and Substance Use, University of New South Wales, Sydney NSW 2052, Australia;3. Northern Sydney Drug and Alcohol Service, Herbert St Clinic, Building 8, Royal North Shore Hospital, St Leonards, NSW 2065, Australia;4. Priority Research Centre for Translational Neuroscience and Mental Health, University of Newcastle, Callaghan, NSW 2308, Australia;5. Drug Health Services, Sydney Local Health District, King George V Building, Missenden Road, Camperdown, NSW 2050, Australia;1. Molecular Neuropsychiatry Research Branch, Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD, USA;2. Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD, USA;3. Gene Expression and Genomics Unit, Intramural Research Program, National Institute of Aging, NIH, DHHS, Baltimore, MD, USA;4. Department of Psychiatry, Center for Neuroproteomics and Biomarkers Research, McKnight Brain Institute of the University of Florida, Gainesville, FL, USA |
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| Abstract: | Preclinical studies indicate that brain-derived neurotrophic factor (BDNF) is involved in neuroplastic changes underlying enduring cocaine-seeking following withdrawal. However, little is known about temporal changes in serum BDNF levels or the involvement of BDNF in craving and abstinence in early-abstinent cocaine-dependent patients. Twenty-three cocaine-dependent individuals (aged 33.65±6.85 years) completed a two-week detoxification program at an inpatient facility. Two serum samples were collected for each patient at baseline and at the end of the protocol. Serum samples were also collected for 46 healthy controls (aged 35.52±9.37 years). Demographic, consumption and clinical data were recorded for all patients. Significantly lower serum BDNF levels (p<.0001) were observed for cocaine-dependent patients at baseline compared to healthy controls. Serum BDNF levels increased significantly across 12 days of early abstinence (p=.030). Baseline BDNF levels correlated with craving (p=.034). Post-detoxification BDNF levels correlated with craving (p=.018), loss of control (p<.000), abstinence measures (p=0.031), depression (p=0.036), and anxiety (p=0.036). Post-detoxification BDNF levels also had predictive value for the loss of control measure of craving. Chronic cocaine use is associated with decreased serum BDNF. A progressive increase in serum BDNF levels during early abstinence correlates with cocaine craving and abstinence symptoms and may reflect increasing BDNF levels in different brain regions. These findings suggest that serum BDNF may be a biomarker for cocaine addiction. |
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