艾灸预处理在癌症患者化疗后骨髓抑制中的应用

目的观察艾灸预处理对癌症患者化疗后骨髓抑制的作用,为临床护理提供依据。方法采用便利抽样法,选取2019年5月-2020年5月江苏省徐州市某三甲医院肿瘤科符合标准的癌症患者70例,最终完成试验的患者有65例,艾灸预处理组(n=20)、艾灸组(n=22)、对照组(n=23)。3组患者均进行正规化疗,艾灸预处理组患者在化疗开始前7 d进行艾灸,每天1次,共14 d;艾灸组患者于化疗开始时进行艾灸,每天1次,共7 d;对照组进行常规化疗。比较3组患者的白细胞计数、中性粒细胞计数、骨髓抑制的发生及分度情况、重组人粒细胞集落刺激因子使用情况。结果3组患者白细胞及中性粒细胞计数组间、不同时间比较,差异均有统计学意义(P<0.05);3组患者化疗后7、14 d骨髓抑制发生情况组间和时间比较,差异均有统计学意义(Waldχ²组间=6.628,P=0.036;Waldχ²时间=43.018,P<0.001);化疗后7、14 d,3组患者使用重组人粒细胞集落刺激因子情况的比较,差异均有统计学意义(P<0.05)。结论艾灸预处理能稳定癌症患者化疗后白细胞及中性粒细胞计数,减少骨髓抑制的发生,减轻骨髓抑制的程度,减少重组人粒细胞集落刺激因子的使用。

Application of moxibustion pretreatment on bone marrow suppression in cancer patients after chemotherapy

Objective To explore the effect of moxibustion pretreatment on bone marrow suppression in cancer patients after chemotherapy,so as to provide a basis for clinical nursing.Methods From May 2019 to May 2020,we selected 70 cancer patients who met the criteria in the Oncology Department of a ClassⅢGrade A hospital in Xuzhou City,Jiangsu Province by convenient sampling.There were 65 patients who finally completed the trial including moxibustion pretreatment group(n=20),moxibustion group(n=22),and control group(n=23).All three groups received regular chemotherapy.Patients in moxibustion pretreatment group received moxibustion 7 days before the start of chemotherapy,once a day,for 14 days;patients in moxibustion group were treated with moxibustion at the beginning of chemotherapy,once a day,for 7 days;control group carried out conventional chemotherapy.We compared the white blood cell count,neutrophil count,incidence and degree of bone marrow suppression,and the use of recombinant human granulocyte colony stimulating factor among the three groups.Results The white blood cell and neutrophil counts of the three groups were compared between the groups and at different times,and the differences were statistically significant(P<0.05).The incidences of bone marrow suppression on the seventh and fourteenth day after chemotherapy of the three groups of patients were compared between the groups and at different times with statistical differences(Waldχ² groups=6.628,P=0.036;Wald χ² times=43.018,P<0.001).A total of 7,14 days after chemotherapy,there were statistical differences in the use of recombinant human granulocyte colony stimulating factor in patients among the three groups(P<0.05).Conclusions Moxibustion pretreatment can stabilize the white blood cell and neutrophil counts of cancer patients after chemotherapy,reduce the incidence of bone marrow suppression,the degree of bone marrow suppression as well as the use of recombinant human granulocyte colony stimulating factor.