盐酸小檗胺降压作用机制的研究

小檗胺为一双苄基异喹啉类生物碱,存在于小檗属植物中;同时也存在于国内药厂用小檗属植物提取过黄连素的废液中,可以回收综合利用,因此,研究小檗胺是有价值的。文献报告,给动物颈动脉及静脉注射小檗胺可引起血压下降。临床上初步试用小檗胺治疗原发性高血压病人,认为有一定疗效。本文观察了小檗胺的降压作用并探讨了它的降压作用机制。

A STUDY ON THE HYPOTENSJVE ACTION AND MECHANISM OF BERBAMINE HYDROCHLORIDE

Berbamine hydrochloride is an alkaloid isolated from Berberis poiretii. The experiments reported here were designed to observe the hypotensive action and mechanism of Berbamine hydrochloride in cats, doga and rabbits, using many models such as intravenous administration, intravertebral arterial administration, in pithed cat, the superior ganglion-nictating membrane preparation in cat, the heart in situ, and the perfused vessel in rat's lower limb. The following results were obtained:Berbamine hydrochloride reduced blood pressure in various animals. The blood pressure was reduced about 20% by giving 5 mg/kg of Berbamine hydrochloride intravenously. As the dose increased to 10 mg/kg (i.v.), the reduction of blood pressure was overIn normal cats, blood pressure was reduced significantly and immediately after vertebral arterial administion. Berbamine hydrochloride 0.5mg increased the fluid flow in perfused rat lower limb.Berbamine hydrochloride showed no superior dervical ganglionic blockade and did not show any antagonism to adrenaline and atropine.These results showed that the hypotensive activity of Berbamine hydrochloride was based on its action on central nervous system and dilatation of blood vessels.