刚地弓形虫DNA疫苗的研究进展

疫苗是防治弓形虫病的有效手段之一。弓形虫疫苗研制经历了全虫疫苗、虫体特异组分疫苗、基因工程疫苗、DNA疫苗等4个发展阶段。弓形虫DNA疫苗较传统疫苗虽有诸多优势，但尚处于研究起步阶段，单价DNA疫苗和佐剂增强型DNA疫苗可诱导机体对弓形虫感染产生细胞免疫和体液免疫，但免疫效果并不理想，复合多重DNA疫苗将是弓形虫疫苗今后的发展趋势。此外，弓形虫DNA疫苗的免疫保护机制和安全性还不十分清楚，进一步探讨疫苗免疫机制和弓形虫免疫逃避机制，将有助于研制高效、安全、实用的弓形虫DNA疫苗。

Research progress on DNA vaccine of Toxoplasma gondii

Vaccine is one of the most effective methods for control of toxoplasmosis. The development of Toxoplasma gondii vaccine includes four phases: live and killed T. gondii vaccines, excreted/secreted antigens as vaccine components, recombinant antigens vaccines and DNA vaccines. Although the DNA vaccines of T. gondii have more advantages, compared with other traditional vaccines, the research on DNA vaccines is still in its infancy. Univalent DNA vaccines and DNA vaccines with various adjuvants can induce cell mediated immunity and humoral immunity against the infection of T. gondii in organism, however,the immunoprotective effects are not ideal. Therefore, it is a popular trend for T. gondii vaccines to develop the combined and multivalent DNA vaccines. In addition, the safety and the mechanism of its immunoprotection are not very clear. To investigate the vaccine immunologic mechanism and immune escape mechanism of T. gondii will be helpful to develop efficient, safe and practical DNA vaccines of T. gondii.