苏黄止咳汤对咳嗽变异型哮喘患者免疫功能的影响

目的探讨苏黄止咳汤对咳嗽变异型哮喘(CVA)患者免疫功能的影响。方法将58例患者随机分为治疗组30例和对照组28例,治疗组予以苏黄止咳汤口服(药物组成:炙麻黄、蝉蜕、地龙、苏叶、炙杷叶、杏仁、五味子等),对照组予以止嗽散汤剂口服(药物组成:桔梗、紫菀、百部、白前、荆芥、陈皮、甘草),连服4周。2组患者治疗前后均抽血测免疫球蛋白及T淋巴细胞亚群。结果2组患者治疗后IgA、IgM差异无显著性(P>0.05),IgG治疗组较对照组明显升高(P<0.05),CD4 无明显变化(P>0.05),CD8 治疗组较对照组明显升高(P<0.05),CD4 /CD8 治疗组较对照组明显下降(P<0.05)。结论苏黄止咳汤可增强咳嗽变异型哮喘患者网状内皮系统活性,调整T淋巴细胞亚群,改善CVA患者免疫功能。

Effect of Suhuangzhike Decoction on immune function in patients with cough variant asthma

Objective To observe the effect of Suhuangzhike Decoction on immune function in patients with cough variant asthma.Method 58 patients with cough variant asthma were divided randomly into Group A(treated with Suhuangzhike Decoction for four weeks) and Group B(treated with Zisou Decoction for four weeks).Immunoglobulin and T lymphocyte subsets in the blood of all these patients were tested before and after treatment.Result There was no significant difference in IgA and IgM(P>0.05) between the two groups and the IgG of the group A was improved significantly when compared with the group B(P<0.05)after treatment.There was no significant difference in CD4 T cells between the two groups(P>0.05),and the CD8 T cells of the group A was increased more than that of the group B(P<0.05)and CD4 /CD8 of the group A was lower than that of the group B(P<0.05)with significant difference after treatment.Conclusion Suhuangzhike Decoction can increase activity of reticular endothelial system,regulate T lymphocyte subsets and improve immune function in patients with cough variant asthma;