| 头孢美唑药物动力学研究 |
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| 引用本文： | 蔡鸿生,张先洲,李荣凌,尹武华.头孢美唑药物动力学研究[J].中国药学杂志,1994,29(8):480-482. |
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| 作者姓名： | 蔡鸿生 张先洲 李荣凌 尹武华 |
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| 作者单位： | 湖北医科大学临床药学研究室 |
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| 摘 要： | 以氯仿－正戊醇（3：1）和磷酸盐缓冲液（pH7．0）2次提取血浆中头孢美唑，用紫外分光光度法测定血药浓度，回收卒98．95％，线性关系良好（C＝245．3A－1．012，r＝0．9996）。头孢美唑在兔体内药动学过程符合二室开放模型，主要药动学多数为：T1/2a＝0．376h，T1/3β＝2．16h，AUC632μg·h·ml-1。
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| 关 键 词： | 头孢美唑 紫外分光光度法 药物动力学 |
| 收稿时间： | 1992-09-15; |
Pharmacokinetics of cefmetazole |
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| CAI Hong-sheng,ZHANG Xian-zhou, LI Rong-ling,LI Guo-ying,YIN Wu-hua.Pharmacokinetics of cefmetazole[J].Chinese Pharmaceutical Journal,1994,29(8):480-482. |
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| Authors: | CAI Hong-sheng ZHANG Xian-zhou LI Rong-ling LI Guo-ying YIN Wu-hua |
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| Institution: | Department of Clini-cal Pharmacology;Hubei Medical University;Wuhan 430060 |
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| Abstract: | Cefmetazole was extractecd bv chloroform-1-pentanol(3: 1 ) and phosphate buffer(pH7. 0) twice from plasma and determined by ultraviolet spectrophotometry. The recovery was98.6%with good linear relation(r=0. 9996). The pharmacokinetic process fited to two-compar-ment open inodel in rabbits。 The main parameters were T1/2a. 376h,T1/3β=2. 16h,and AUC 632μg·h·ml-1。 |
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| Keywords: | cefmetazole UV pharmacokinetics |
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