| 局部外用他克莫司治疗皮肤病 |
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| 引用本文： | 顾有守. 局部外用他克莫司治疗皮肤病[J]. 国际皮肤性病学杂志, 2006, 32(1): 59-62 |
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| 作者姓名： | 顾有守 |
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| 作者单位： | 510500,广州,广东省皮肤性病防治中心 |
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| 摘 要： | 他克莫司是一种大环内酯类免疫抑制剂,其作用机制与环孢素相似,全身应用主要用于预防异体器官移植的排斥反应以及治疗免疫性疾病。与环孢素不同的是,由于它相对分子质量相对较小,可以穿透表皮屏障,为避免全身不良反应的发生,可制成外用制剂治疗各种免疫性和炎性皮肤病。
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| 关 键 词： | 他克莫司 皮肤疾病 治疗 |
| 收稿时间： | 2005-06-27 |
| 修稿时间： | 2005-06-27 |
Topical Application of Tacrolimus in Skin Diseases |
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| GU You-shou. Topical Application of Tacrolimus in Skin Diseases[J]. International Journal of Dermatology and Venereology, 2006, 32(1): 59-62 |
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| Authors: | GU You-shou |
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| Abstract: | Tacrolimus is a macrolide immunosupressant. The mechanism of its action is similar to that of cy-closporine. Systemic tacrolimus is mostly used in the prevention of rejection after organ transplantation and in the treatment of immune diseases. Since the molecular weight of tacrolimus is low, it can penetrate the epidermal barrier, which is different from cyclosporine. In order to avoid systemic side effects, topical agents of tacrolimus have been manufactured for the treatment of immune and inflammatory dermatoses. This article reviews the topical use of tacrolimus ointment in the treatment of skin diseases. |
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| Keywords: | Tacrolimus Skin diseases Therapy |
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