适量饮酒对健康成年男性血浆TXB2,6-Keto-PGF2a及血小板聚集功能的影响

①目的　观察适量饮酒对健康成年男性的血小板聚集功能及血浆血栓素B2 (TXB2 ) ,6 酮 前列腺素F2a(6 Keto PGF2a)的影响。②方法　将 80例健康成年男性随机分成 4组 ,分别空腹饮用矿泉水、啤酒、干红葡萄酒各 2 0 0mL ,白酒 50mL加矿泉水至 2 0 0mL .于饮前及饮后 2h分别测定血小板的聚集率及解聚率 ,并采血测定血浆TXB2 ,6 Keto PGF2a.③结果　矿泉水组饮后上述指标无变化 (t=0 .0 3～ 0 .84,P >0 .0 5) ;白酒、啤酒、红葡萄酒组饮后血小板聚集率减低 (t=8.1 2～ 2 4 .39,P <0 .0 1 ) ,解聚率升高 (t=2 8.48～ 35 .2 2 ,P <0 .0 1 ) ,血浆TXB2 降低 (t=2 5 .69～ 89.83 ,P <0 .0 1 ) ,而血浆 6 Keto PGF2a升高 (t=2 1 .0 6～ 2 3 .2 9,P <0 .0 1 )。④结论　健康成年男性适量饮酒可减低其血小板聚集功能 ,降低其血浆TXB2 ,提高其血浆 6 Keto PGF2a水平

THE EFFECTS OF MODERATE ALCOHOL CONSUMPTION ON THE FUNCTIONS OF PLATELET AND PLASMA TXB2,6-Keto-PGF2a IN HEALTHY MEN

Objective To evaluate the effects of moderate alcohol drinking on the functions of platelet and plasma TXB 2,6 Keto PGF 2a in healthy men. Methods 80 men were divided randomly into four groups. Group 1, 200 mL of mineral water; Group 2, 200 mL of beer; Group 3, red wine, 200 mL; and Group 4, liquor 50 mL plus 150 mineral water. All were given on an empty stomach. The functions of platelet and the levels of the plasma TXB 2 and 6 Keto PGF 2a were detected before and after the detection. Results The above parameters did not change for Group 1 ( t=0.03-0.84,P>0 .05). For Groups 2, 3 and 4, the platelet impedance reduced ( t=8.12-24.39,P <0.01), fibrinolysis rate increased ( t=28.48-35.22, P <0.01), and plasma TXB 2 level decreased ( t=25.69-89.83, P <0.01).The level of plasma 6 Keto PGF 2a increased ( t=21.06-23.29, P <0.01). Conclusion Moderate alcohol consumption can improve the functions of platelet and decrease the TXB 2 levels and increase plasma 6 Keto PGF 2a .