高同型半胱氨酸兔模型腹主动脉超声表现的实验研究

目的 探讨兔同型半胱氨酸(HCY)与动脉粥样硬化(AS)的发生、发展的关系。方法 雄性新西兰大白兔18只，采用蛋氨酸饮食负荷复制出兔高同型半胱氨酸模型，同时以高脂血症模型为阳性对照，分别于0、4、8周对腹主动脉进行超声检查，记录腹主动脉狭窄程度及硬化斑块形成，并与病理相对照。结果 4周时高脂饮食组显示腹主动脉硬化斑块及动脉狭窄，8周时高蛋氨酸饮食组显示腹主动脉硬化斑块及动脉狭窄，并得到病理证实。统计学分析提示血浆同型半胱氨酸浓度与胆固醇浓度分别与腹主动脉狭窄程度呈正相关，但血浆胆固醇浓度与同型半胱氨酸浓度无显著相关。结论 高同型半胱氨酸是动脉粥样硬化的一个相对独立的重要危险因素。

Experimental ultrasonographic study of abdominal aorta in diet-induced hyperhomocysteinemia rabbits

Objective To investigate the relation between serum homocysteine(HCY) and the development of atherosclerosis(AS).Methods Diet contained 1% methionine was fed to make models of hyperhomocysteinemia and atherosclerosis in 18 male New Zealand rabbits. Hyperlipemia group was as control group. Ultrasonographic image was performed in 0,4,8 weeks respectively with HP 8500 and recorded the stenosis and plaque of abdominal aorta compared with pathology.Results Stenosis and plaque of abdominal aorta were observed in 4 weeks in high fat diet group. Stenosis and plaque of abdominal aorta were observed in 8 weeks in high methionine diet group.This results were confirmed by pathology anatomy.Satistically,significant correlation was found between AS and hypercholesterolemia or hyperhomocysteinemia respectively.But there was no correlation between hypercholesterolemia and hyperhomocysteinemia. Conclusions Hyperhomocysteinemia is an independent important risk factor of atherosclerosis.