Suramin inhibits respiration and induces membrane permeability transition in isolated rat liver mitochondria. |
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| Authors: | C F Bernardes M M Fagian J R Meyer-Fernandes R F Castilho A E Vercesi |
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| Affiliation: | Departamento de Patologia Clínica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP 13083-970, Brazil. mfagian@obelix.unicamp.br |
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| Abstract: | Suramin, a polysulfonated naphthylamine, caused a dose dependent inhibition of carbonyl cyanide p-(tri-fluoromethoxy)phenylhydrazone-stimulated respiration supported either by succinate or a cocktail of alphaketoglutarate, malate and isocitrate in isolated rat liver mitochondria. The half-maximum effect was obtained at 40 and 140 microM suramin for NADH- or FADH(2)-linked substrates, respectively. The respiration supported by N,N,N'N'-tetramethyl-p-phenylenediamine oxidation was unaffected by suramin (
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