| 槲皮素对人肝癌HepG2细胞的作用与机制 |
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| 引用本文： | 曾文铤,唐武兵,倪宏,马佩球,朱科伦. 槲皮素对人肝癌HepG2细胞的作用与机制[J]. 中西医结合肝病杂志, 2003, 13(1): 17-19 |
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| 作者姓名： | 曾文铤 唐武兵 倪宏 马佩球 朱科伦 |
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| 作者单位： | 广州医学院第一附属医院肝病研究室,广东,广州,510120 |
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| 基金项目： | 广东省中医药管理局、广州医学院第一附属医院科研基金(101045) |
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| 摘 要： | 目的：探讨槲皮素（Qu)对人肝癌HepG2细胞的作用及其对人肝癌HepG2细胞化疗效果的影响。方法：体外培养传代人肝癌细胞系HepG2细胞，以甲基噻唑基四唑（MTT）法和荧光染色法检测不同浓度Qu及联合阿霉素（ADM）对HepG2细胞抑制率和细胞凋亡率的影响，并进行比较，结果：Qu能抑制人肝癌HepG2细胞生长，诱发细胞凋亡，能提高抗HepG2细胞化疗效果。结论：Qu具有抗肝癌HepG2细胞和化疗增敏作用。
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| 关 键 词： | 槲皮素 人肝癌HepG2细胞 作用 |
| 修稿时间： | 2002-10-12 |
The Role and Mechanism of Quercetin on Human Heptocarcinoma Cell Line HepG2 |
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| ZENG Wenting,TANG Wubing,NI Hong,et al.. The Role and Mechanism of Quercetin on Human Heptocarcinoma Cell Line HepG2[J]. Chinese Journal of Integrated Traditonal and Western Medicine on Liver Diseases, 2003, 13(1): 17-19 |
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| Authors: | ZENG Wenting TANG Wubing NI Hong et al. |
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| Affiliation: | ZENG Wenting,TANG Wubing,NI Hong,et al. Department of Hepatology Research,First Affiliated Hospital of Guangzhou Medical College |
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| Abstract: | Objective: In order to understand the effects of Quercetin that was aimed at the human heptocarcinoma cell line HepG2 and chemotherapy on human heptocarcinoma cells. Methods: HepG2 cells were cultured in vitro, the rates of inhibit HepG2 and apoptosis were detected by MTT and fluorescent staining. Results: Quercetin was possible to inhibit HepG2 cells from growth, evoke to apoptosis and rise to the effect of ADM chemotherapy. Conclusion: Quercetin possibly resistance the HepG2 cells and sensitize to chemotherapy. |
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| Keywords: | Oncology Hepatoma Experimental Quercetin/Pharmacodynamics Adriamycin/Therapeutic Use Human Heptocarcinoma Cell Line Methyl Thiazolyl Tetrazolium Microfluorometry |
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