血清C反应蛋白、血脂与肾病综合征的相关性研究

目的：探讨血清C反应蛋白、血脂水平与原发性肾病综合征的相关性。方法将45例原发性肾病综合征患者设为观察组，45例健康查体者设为对照组，分别检测两组人员血液中的C反应蛋白、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）及脂蛋白-a水平，分析两者的差异性。结果观察组患者的C反应蛋白水平明显高于对照组（P〈0.01）；在血脂水平方面，观察组患者的TC、TG、LDL-C及脂蛋白-a水平均明显高于对照组（P〈0.05），而观察组HDL-C水平与对照组组间比较无明显差异（P＞0.05）。结论肾病综合征患者常合并严重的脂质代谢紊乱及微炎症反应，表现为血清C反应蛋白及血脂水平均明显高于健康人群，可以作为诊断原发性肾病综合征的辅助生化指标。

The correlation between serum C -reactive protein,blood lipids and nephrotic syndrome

Objective To study relation of serum C-reactive protein （CRP） and lipid level with primary nephrotic syndrome（PNS）. Methods Selected 45 patients with primary nephrotic syndrome were set as observation group,and 45 cases of healthy physical examination were set as control group, the levels of CRP,TC,TG,HDL-C,LDL-C and Lp（a） between the observation group and control group were compared. Results The level of CRP in observation group was significantly higher than that in the control group（P〈0.01）;in the aspect of lipid level,the level of the TC, TG, LDL-C and Lp（a） inobservation group were also higher than those in another group,and there was statistic difference（P〈0.05）,but HDL-C level had no difference between them. Conclusion Primary nephritic syndrome is combination with sever disorder of lipid metabolism,and the serum c-reactive protein and lipid levels in PNS were significantly higher than that of healthy people,which can be used as the auxiliary diagnosis index for nephrotic syndrome.