徐州市1998-2004年出生儿童HBV—M血清流行病学调查

目的了解徐州市乙肝疫苗纳入计划免疫后出生儿童乙肝病毒（HBV）感染状况及其原因，为采取进一步降低乙肝病毒感染的措施提供依据。方法采用整群分层随机抽样的方法，共选择1995名儿童作为研究对象，用ELISA法检测HBV—M，采用病例——对照研究分析HBsAg阳性原因。结果．徐州市1998—2004年间出生儿童的HBsAg、抗-HBs、抗-HBc、HBeAg、抗-HBe阳性率分别为0．80％、50．58％、0．65％、0．70％和0．15％。其中，16例HBsAg携带者中，13例抗-HBs、HBeAg同时阳性。母亲为HBsAg阳性的子女成为HBsA异阳性的危险性是阴性母亲子女的67．67倍。结论实施乙肝疫苗计划免疫后，我市儿童乙肝病毒感染率已降到较低水平。母婴阻断失败是感染的重要原因，应加强乙肝母婴传播阻断对策的研究。

Investigation on HBV infection Markers in the Children Born among the years of 1998-2004 in Xuzhou City

OBJCTIVE To evaluate the distribution of HBV infection markers of 1-7 years children and determine the cause for further lowing the positive rate.METHOD Cluster sampling method was used to select 1 995 children,the method of ELISA was used to test the HBV-M,case-control study was performed to analysis the cause of HBsAg positive.RESULTS The HBsAg,anti-HBs,anti-HBc,HBeAg and anti-HBe positive rate in the children born among the years of 1998-2004 are 0.80%,50.58%,0.65%,0.70%,0.15% respectively.The children's carring of HBsAg are most attributed to mother-infant transmission.CONCLUSION The HBV infection rate is much more lower in children then before after implementing programed HB vaccination.It meeds more powerful methods to control mother-infant transmission.