Recombinant human LH supplementation during GnRH antagonist administration in IVF/ICSI cycles: a prospective randomized study |
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Authors: | Cédrin-Durnerin I Grange-Dujardin D Laffy A Parneix I Massin N Galey J Théron L Wolf J P Conord C Clément P Jayot S Hugues J N |
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Affiliation: | Centre for Reproductive Medicine, Jean Verdier Hospital, A.P.-H.P., 93143 Bondy--University Paris XIII, France. isabelle.cedrin-durnerin@jvr.ap-hop-paris.fr |
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Abstract: | BACKGROUND: When administered in the late follicular phase to prevent an LH surge, GnRH antagonists induce a sharp decrease in serum LH levels that may be detrimental for assisted reproductive technology cycle outcome. Therefore, a prospective study was designed to assess the effects of recombinant human (r)LH supplementation during GnRH antagonist (cetrorelix) administration. METHODS: The protocol consisted of cycle programming with oral contraceptive pill, ovarian stimulation with rFSH and flexible administration of a single dose of cetrorelix (3 mg). A total of 218 patients from three IVF centres were randomized (by sealed envelopes or according to woman's birth date) to receive (n = 114) or not (n = 104) a daily injection of rLH 75 IU from GnRH antagonist initiation to hCG injection. RESULTS: The only significant difference was a higher serum peak E2 level in patients treated with rLH (1476 +/- 787 versus 1012 +/- 659 pg/ml, P < 0.001) whereas the numbers of oocytes and embryos as well as the delivery rate (25.2 versus 24%) and the implantation rate per embryo (19.1 versus 17.4%) were similar in both groups. CONCLUSIONS: These results show that in an unselected group of patients, there is no evident benefit to supplement GnRH antagonist-treated cycles with rLH. |
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Keywords: | assisted reproductive technology/controlled ovarian stimulation/GnRH antagonist/rLH |
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