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HLA-B Alleles Associated with the B15 Serologically Defined Antigens |
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| Authors: | Noriko Steiner Jennifer Ng Janet Bush Robert J. Hartzman Leslie Johnston-Dow Carolyn Katovich Hurley |
| Affiliation: | A Department of Microbiology and Immunology, Georgetown University Medical School, Washington, DC, USA (N.S., C.K.H.), B Department of Pediatrics, Georgetown University Medical School, Washington, DC, USA (J.N., J.B.), C Naval Medical Research Institute, Bethesda, MD, USA (J.N., R.J.H.) D PE-Applied Biosystems, Foster City, CA, USA (L.J-D.). |
| Abstract: | ABSTRACT: Cells expressing HLA molecules in the B15 family were identified by serologic typing in routine testing of volunteer donors of various ethnic backgrounds for a bone marrow registry. DNA sequencing was used to identify HLA-B15 alleles associated with each serologic type and to examine the diversity within the B15 antigen family. Alleles which appeared predominantly in each B15 serologic cluster included: B15 with no defined serologic subdivision (B*1501), B62 (B*1501), B63 (B*1516, B*1517), B75 (B*1502, B*1521), and B76/77 (B*1513). Other B*15 alleles were also found associated with the serotypes and some of these alleles (e.g., B*1501 and B*1516) were found in two or more serologic clusters illustrating the complexity of this family. The B15 unsplit and B75 groups were the most complex exhibiting 16 and 7 alleles, respectively, within each serotype. Five new B*15 alleles (B*1530, B*1531, B*1533, B*1534, B*1535) and 5 other new HLA-B alleles (B*38022, B*3910, B*4010, B*51012, and B*5108) were also identified. |
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