Decreased Prohepcidin Levels in Patients with HBV-Related Liver Disease: Relation with Ferritin Levels |
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Authors: | Oya Yonal Filiz Akyuz Kadir Demir Sevgi Ciftci Fahriye Keskin Binnur Pinarbasi Ahmet Uyanikoglu Halim Issever Sadakat Ozdil Gungor Boztas Fatih Besisik Sabahattin Kaymakoglu Yilmaz Cakaloglu Zeynel Mungan Atilla Okten |
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Affiliation: | 1. Department of Gastroenterohepatology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey 2. Department of Microbiology, Istanbul Faculty of Dentistry, Istanbul University, Istanbul, Turkey 3. Department of Biostatistics, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
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Abstract: | Background Levels of prohepcidin, a homeostatic regulator of iron absorption, are altered in chronic hepatitis C and liver cirrhosis. However, data on the potential alterations of prohepcidin in patients with HBV-related liver disease are scarce. We investigated whether serum prohepcidin is related to iron overload and perenchymal dysfuction in HBV-related liver disease. Methods Three groups of subjects were studied: 66 patients with chronic hepatitis B, 32 patients with HBV-related cirrhosis, and 42 healthy controls without evidence of liver disease. Serum levels of prohepcidin were determined by enzyme-linked immunosorbent assay. Results Serum prohepcidin levels were significantly lower in patients with HBV-related cirrhosis (175.85 ± 71.5 ng/ml) than in patients with chronic hepatitis B (209.02 ± 62.7 ng/ml P < 0.05) and controls (222.4 ± 128.4 ng/ml, P < 0.05). After adjustment for potential confounders, prohepcidin was found to be an independent predictor of ferritin levels in multiple linear regression analysis (β = ?1.10, t = ?3.11, P < 0.01). Conclusion These results demonstrate that prohepcidin levels are reduced in patients with HBV-related cirrhosis and are an independent correlate of serum ferritin. |
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