SARS患者影像学表现与各免疫学指标的相关性研究

目的研究严重急性呼吸综合征(severeacuterespiratorysyndrome,SARS)患者病程中各免疫学指标的变化与患者影像学表现的相关性,阐明患者影像学改变的免疫学基础。方法收集、整理2003年3月至7月期间在北京非典型肺炎定点医院确诊SARS患者临床资料,建立SARS病历数据库。其中病历完整的为1291例,记录SARS患者发病1～5周的白细胞、CD3、CD4、CD8阳性淋巴细胞绝对值、血沉、C反应蛋白以及患者的影像学发现的病变范围等数据,研究SARS患者各免疫学指标的变化与影像学病变范围的相关性并进行统计学分析。结果影像学病变范围广的SARS患者白细胞、CD3、CD4、CD8阳性淋巴细胞比病变范围小的患者明显减少(P<0.05),病变范围广者炎症指标升高明显(P<0.05)。影像学表现随时间变化,并且与白细胞、CD、CD、CD阳性淋巴细胞的变化同步。结论影像学表现与免疫指标变化有时间的一致性。

Study on the relationship between radiological presence and immune indies in patients with SARS

Objective To study the relationship between presence of radiology and immune indies in patients with SARS.Methods Clinical data from 1291 patients with SARS during March and July in 2003 were retrospectively analyzed.Data include WBC count,lymphocyte count,CD_3,CD_4,CD_8lymphocytes,ESR and radiological changes.Results A significant descent of WBC and T lymphocyte subgroup showed the immune systems of SARS patients were impaired,and cellular immune system was seemly as the main target tissue.The patients with more extensive pulmonary lesion had lower WBC and T lymphocyte subgroup count(P<0.05).Radiological changes fallowed the change of immune indies.Conclusion Radiological changes coincide with alteration of immune indies.