丹地片对绝经后女性血脂及性激素的影响

目的：探讨补肾活血剂——丹地片对绝经后女性血脂及性激素的影响。方法：将73例绝经后女性随机分为两组，丹地组(46例)采用丹地片(由熟地24g 山茱萸9g 茯苓9g 泽泻9g 牡丹皮9g 淮山药12g 丹参15g等组成)治疗，每次4片，每日2次，对照组(27例)口服维尼安(乙炔雌二醇戊醚，每片含2．5mg)，每月5mg，连用3个月，分别于治疗前后测定血脂(TC、TG、HLD-C、LDL-C)、载脂蛋白(apoA、apoB)及性激素(FSH、E2)水平。结果：两组治疗后TC／HLD-C、FSH下降，HDL-C、E2上升，与治疗前比较，差异均有显著性(P<0．05或P<0．01)；且丹地组TG下降，apoA上升，与治疗前比较，差异亦有显著性(P<0．05)。结论：丹地片具有提高雌激素水平，改善血脂代谢的作用，对绝经后妇女冠心病的发生有预防作用。

Effect of Dandi Tablet on Blood Lipids and Sex Hormones in Women of Postmenopausal Stage

OBJECTIVE: To explore the effect of Dandi Tablet (DDT), a TCM preparation for tonifying Shen and activating blood circulation, on blood lipids and sex hormones in women of postmenopausal stage. METHODS: Seventy-three women were randomly divided into two groups. The 46 subjects in the DDT group were treated with DDT (consisted of prepared Rehmannia Root 24 g, Dogwood Fruit 9 g, Poria 9 g, Water-plantain 9 g, Tuber Peony bark 9 g, Chinese Yam 12 g and Red Sage 15 g, etc.) twice a day, 4 tablets each time. The 27 subjects in the control group were treated with nylestriol (each tablet contains 2.5 mg of 17 alpha-ethynylestriol-3-cyclopentyl ether) 5 mg every month, for 3 successive months. Levels of blood lipids, including total cholesterol (TC), triglyceride (TG), high and low density lipoprotein cholesterol (HDL-C, LDL-C), apoprotein A and B (apoA, apoB) and sex hormones, including follicular stimulating hormone (FSH) and estradiol (E2) were determined before and after treatment. RESULTS: Compared with pre-treatment, after treatment, levels of TC/HDL-C and FSH significantly lowered, HDL-C and E2 increased in both groups (P < 0.05 or P < 0.01), levels of TG lowered and apoA increased significantly in the DDT group (P < 0.05). CONCLUSION: DDT has the effect of elevating levels of estrogen and improving blood lipid metabolism, therefore shows a coronary heart disease preventive effect in women of postmenopausal stage.