| 烟酰胺在皮肤科的应用进展 |
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| 引用本文： | 黄畋,林熙然. 烟酰胺在皮肤科的应用进展[J]. 国际皮肤性病学杂志, 2009, 35(2). DOI: 10.3760/cma.j.issn.1673-4173.2009.02.010 |
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| 作者姓名： | 黄畋 林熙然 |
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| 作者单位： | 1. 大连医科大学附属第二医院皮肤科,116027
2. 大连医科大学附属第一医院皮肤科 |
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| 摘 要： | 研究显示,烟酰胺腺嘌呤二核苷酸不但是细胞氧化还原的辅酶,而且是单腺苷酸二磷酸核糖转移酶、多聚单腺苷酸二磷酸核糖聚合酶和去乙酰化酶的底物,在多种细胞生理学功能中超重要作用.烟酰胺是合成烟酰胺腺嘌呤二核苷酸的前体,又是烟酰胺腺嘌呤二核苷酸一消耗酶的抑制剂,其作用已超出于防治糙皮病.在皮肤科,烟酰胺已用于治疗免疫性大疱病、特应性皮炎、痤疮和酒渣鼻等,并在抗皮肤老化和皮肤美容方面有良好的应用前景.烟酰胺外用的安全性已经确认,但大剂量内服尚未经规范的新药安全性评估.
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| 关 键 词： | 烟酰胺 皮肤疾病 治疗应用 |
Advances in the application of nicotinamide in dermatology |
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| HUANG Tian,LIN Xi-ran. Advances in the application of nicotinamide in dermatology[J]. International Journal of Dermatology and Venereology, 2009, 35(2). DOI: 10.3760/cma.j.issn.1673-4173.2009.02.010 |
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| Authors: | HUANG Tian LIN Xi-ran |
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| Abstract: | Recent studies have shown that nicotinamide adenine dinucleotide(NAD)is not only a co-enzyme in cellular oxidation.reduction reactions.but also a substrate for reactions catalyzed by mono (ADP-ribose) transferases,poly (ADP-ribose) polymemses and acetylase,and it play important roles in numerous cellular physiologic functions.Nicotinamide is not only a precursor for the synthesis of NAD,but also an inhibitor of NAD-consuming enzymes.Besides pellagra,nicotinamide has been used to ireat immune bullous diseases,atopic dermatitis,rosacea and aene,and so on.Moreover,nicotinamide has shown a favorable perspective in anti-skin aging and cosmetic dermatology.The safety of topical nicotinamide has been already confirmed.but a forlnal safety evaluation routinely designed for a new drug has not been performed for oral nicotinamide at high dose. |
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| Keywords: | Niacinamide Skin diseases Therapeutic uses |
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