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Donor cell-derived acute myeloid leukemia after second allogenic cord blood transplantation in a patient with Fanconi anemia
Authors:Gustafsson Britt  Moell Jacob  Leblanc Katarina  Barbany Gisela  Söderhäll Stefan  Winiarski Jacek
Affiliation:Astrid Lindgren Children's Hospital, Karolinska University Hospital-Huddinge, Sweden. britt.gustafsson@ki.se
Abstract:DCL following hematopoietic stem cell transplantation has been reported in approximately 5% of all leukemic relapses. There have been several reports on DCL, mainly AML after umbilical cord blood transplantation. In this case study, we present a young boy diagnosed with Fanconi anemia who underwent an umbilical cord blood transplantation. Because of the graft failure, he was retransplanted one month later, also with a cord blood transplant. Two years after the second transplant, he developed AML, where 100% of the cells were of female donor origin. The donor, a now 14-yr-old female, was recently reported healthy.
Keywords:acute myeloid leukemia  cord blood transplantation  donor cell leukemia leukemic infiltration
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