饮用加银水对尾吊大鼠脂质代谢的影响

目的 研究饮用加银水对尾吊模拟失重大鼠红细胞膜流动性、血脂和血管内皮细胞的影响。方法 30只SD雄性大鼠随机分为地面对照组(GC组)、模拟失重对照组(SC组)和模拟失重饮用0．20mg／L加银水组(SS组)，实验期21d。观察大鼠血脂指标、红细胞膜流动性以及脱落循环内皮细胞数量的变化。结果 SC组大鼠血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)水平、HDL-C／TC比值以及红细胞膜流动性低于GC组，LDL-C(低密度脂蛋白胆固醇)／HDL-C比值和脱落循环内皮细胞数量高于GC组。SS组和SC组比较，SS组大鼠血清TC、LDL-C和LDL-C／HDL-C比值增高，HDL-C／TC比值和红细胞膜流动性降低。结论 长期饮用0．20mg／L加银水可以加重尾吊模拟失重大鼠脂质代谢的紊乱。

Effects of Silverionized Drinking Water on Lipids Metabolism in Tail-suspended Rats

Objective To study the effect of silverionized drinking water on erythrocyte membrane fluidity,serum lipids and vascular endothelial cells in tail-suspended rats. Method Thirty male SD rats were randomly divided into ground control group(GC),simulated weightlessness control group(SC), simulated weightlessness and silverionized water drinking group(SS). Number of circulating endothelial cells(CEC),serum lipids and erythrocyte membranes fluidity was measured on the 21st day of tail suspension. Result Levels of serum TC,TG,HDL-C,HDL-C/TC and erythrocyte membrane fluidity in SC rats were significantly lower than those in GC rats; LDL-C/HDL-C ratio and number of CEC in SC rats were markedly higher than those in GC rats. Levels of serum TC,LDL-C and LDL-C/HDL-C in SS rats were higher than those in SC rats; HDL-C/TC ratio and erythrocyte membrane fluidity in SS rats were lower than those in SC rats. Conclusion Drinking silverionized water has a negative effect on lipid metabolism in tail-suspended rats.