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Cerebellar liponeurocytoma: Morphological,immunohistochemical, and ultrastructural study of a relapsed case
Authors:Anna Maria Buccoliero  Adele Caldarella  Stefano Bacci  Pasquale Gallina  Antonio Taddei  Nicola Di Lorenzo  Paolo Romagnoli  Gian Luigi Taddei
Abstract:Cerebellar liponeurocytoma is a rare and newly identified neoplasm found in adults which is reputed to be benign. Its salient morphological characteristics are advanced neuronal/neurocytic differentiation, the presence of lipomatous areas, low mitotic rate, and the absence of necrosis, pleomorphism and vascular hyperplasia. Reported is a case of relapsing liponeurocytoma which occurred 3 and a half years after the radical excision of the primary lesion. Histopathological aggressive features (mitoses and a high proliferation index as evaluated by MIB‐1) were shown in the primary lesion and recurrence of the tumor. We suggest that liponeurocytoma is an uncertain malignant potential lesion when mitoses are present and the MIB‐1 positive cells are more than 10%.
Keywords:electron microscopy  lipidized medulloblastoma  lipomatous medulloblastoma  medullocytoma  photon radiosurgery system
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