2型糖尿病患者血清hs-CRP与左室功能关系的研究

【目的】探讨2型糖尿病患者血清超敏C反应蛋白（hs—CRP）水平与左室功能的关系。【方法】以本院连续诊治的218例2型糖尿病患者为研究对象，入院当天抽血测定hs—cRP的浓度；次日行心脏超声检查，评价左室功能，并测试6分钟步行试验以评估患者的运动耐量。【结果】根据hs—CRP水平分为高hPCRP组（n=164）和低hs—CRP组（n=54），心脏超声提示与低hs—CRP组相比较，高hs—CRP组左室射血分数（LVEF）（41．3±9．8％vs53．7±8．6％，P〈0．01）、短轴缩短率（FS）[（21．5±7．1）％vs（27．68±8．8）％，P〈0．01]明显减低，左室舒张末期容积（LVEDV）[（69．3±15．6）mt＇vs（52．1±13．4）mL，P〈0．05]、左室心脏质量指数（LVMI）[（140．2±19．5）g／m^2vs（108．7±18．3g／m^2），P〈0．01]明显增加；高hs—CRP组的6分钟步行距离显著低于低hs—CRP组[（432．7±35．7）mvs（586．6±46．3）m，P〈0．01]。【结论】血hs—cRP水平可作为2型糖尿病患者心功能不全的参考指标，hs—CRP水平愈高，左室功能越差，运动耐量越低。

Relationship Between Serum High Sensitivity C-reactive Protein Level and Left Ventricular Function in Type 2 Diabetes Mellitus Patients

[Objective]To explore the relationship of high sensitivity C-reactive protein（hs-CRP） level and left ventricular function in type 2 diabetes mellitus. [Methods]A total of 218 patients with type 2 diabetes mellitus were consecutively included into the study. At day of admission, hs-CRP concentration was measured. And left ventricular function was evaluated by echocardiogram at next day. Six-minute walking test was performed to assess exercise capacity. [Results]All patients were divided into high hs-CRP（ n=164）group and low hs-CRP（ n=54）group. LVEF（41.3±9.8% vs 53.7±8. 6%, P〈0.01）and FS（21.5±7.1% vs 27.68±8.80//00, P〈0.01） in high hs-CRP group were significantly lower than those in low hs-CRP group while LVEDV（69.3±15.6 mL vs 52.1±13.4 mL, P〈0.05） and LVMI （140.2±19.5 g/m^2 vs 108.7±18.3 g/m^2, P〈0.01） were significantly higher. Distance of six-minute walking test in high hs-CRP group was significantly lower than that in low hs-CRP group. [Conclusion] Serum hs-CRP level can serve as a reliable biomarker for cardiac dysfunction in patients with type 2 diabetes mellitus. The higher hs-CRP level suggests lower left ventricular function and exercise capacity.