PARP-1在舌鳞癌组织中的表达及意义

目的检测PARP-1在舌鳞癌中的表达水平,分析与舌鳞癌患者临床病理因素及预后的相关性,初步探讨PARP-1在舌鳞癌的预后价值。方法采用免疫组织化学法检测155例舌鳞癌组织及13例邻近正常舌组织的石蜡组织切片中PARP-1的表达水平,分析PARP-1的表达水平与舌鳞癌患者的临床病理因素及预后的相关性。结果155例舌鳞癌组织中,PARP-1阳性表达率为89.0%(138/155),其中58.1%(90/155)呈高表达,41.9%(65/155)呈低表达;13例邻近正常舌组织均无PARP-1表达,两者比较差异有统计学意义(χ²=64.815,P=0.000)。PARP-1的表达水平与患者的T分期(χ² =10.841,P=0.002)、N分期(χ²=8.962,P=0.007)、病理分期(χ²=17.151,P=0.000)呈正相关。PARP-1高表达者总生存时间(P=0.037)与无瘤生存时间(P=0.026)比低表达者短。结论PARP-1可能是促进舌鳞癌发生发展的癌基因,具有预测舌鳞癌预后的临床价值。

Expression and Significance of Poly (ADP-ribose) Polymerase 1 in Oral Tongue Squamous Cell Carcinoma

Objective To detect the expression level and prognostic value of poly(ADP-ribose) polymerase 1(PARP-1) in oral tongue squamous cell carcinoma(OTSCC),and to analysis the relationship between PARP-1 expression and the clinicopathologic characteristics and prognosis of patients.Methods Expression of PARP-1 in 155 paraffin-embedded specimens of OTSCC and 13 paraffin-embedded specimens of adjacent normal tongue mucosa tissues was detected by the immunohistochemical method.The relationship between PARP-1 expression and the clinicopathologic characteristics and prognosis of patients was analyzed.Results Expression of PARP-1 was observed in 89.0%(138/155) of 155 OTSCC specimens.Overexpression of PARP-1 was observed in 58.1%(90/155) of the 155 OTSCC Paraffin specimens,while low expression of PARP-1 was 41.9%(65/155).Expression of PARP-1 was not observed in 13 normal tongue specimens.There was a significant difference between the 2 groups(χ2=64.815,P=0.000).Expression of PARP-1 positively correlated to T stage(χ2=10.841,P=0.002),N stage(χ2=8.962,P=0.007) and pathological stage(χ2=17.151,P=0.000).The overall survival(P=0.037) and disease free survival(P=0.026) were shorter in patients with overexpression of PARP-1.Conclusion PARP-1 may play an important role in carcinogenesis and cancer progression of OTSCC.PARP-1 may have a prognostic value in OTSCC.