胃印戒细胞癌临床病理特征研究

目的通过对比胃印戒和非印戒细胞癌患者的临床资料，分析胃印戒细胞癌的病理特征。方法对110例胃印戒细胞癌(SRC)及同期326例非印戒细胞癌（NSRC)的临床病理特点进行回顾性分析。结果印戒细胞癌组患者男女比例(1.4∶1)明显小于非印戒细胞癌组(2.5∶1)（P<0.01）；印戒细胞癌组患者发病年龄<60岁的比例（43.6%）明显高于非印戒细胞癌组（30.9%）（P<0.05）；在Ⅰ期胃癌患者，胃印戒细胞癌患者所占比为31.4%，而Ⅰ期以上印戒细胞癌患者在所有晚期胃癌患者中所占比为23.3%（P<0.05）；印戒细胞癌组中肿瘤浸润深度达T1以上者（70%）低于非印戒细胞癌组(86.9%)（P<0.001）；而两组在肿瘤发生部位、淋巴结转移率上的差异无统计学意义。结论胃印戒细胞癌好发于年轻女性，早期发生率较高且浸润到黏膜下层速度较慢。

Clinicopathological Characteristics of Gastric Signet Ring Cell Carcinoma

Objective To analyze the clinicopathological characteristics of patients with SRC in comparison with non-signet ring cell carcinoma(NSRC) of the stomach.Methods Retrospective study on the clinicopathological characteristics of 110 patients with SRC and 326 patients with NSRC.Results In this study,the proportion of men and women in SRC(1.4∶1) is lower than in the NSRC group(2.5∶1)(P<0.01);among all the patients younger than 60 years old,the morbidity of SRC(43.6%) is higher than that of NSRC(30.9%)(P<0.05);the proportionality of SRC is 31.4% of all the patients with gastric cancer in stage Ⅰ,and 23.3% in the other stages(P<0.05);the proportion of the tumor which infiltrate into submucosa is lower in the SRC group(70%)than the NSRC group(86.9%)(P<0.001);but no significant differences in tumor location or lymph node metastasis between two groups(SRC and NSRC).ConclusionSignet ring cell carcinoma happens more commom in young females and the incidence rate is higher in early carcinoma and infiltrates more slowly in submucosa than mucosa.