文拉法辛与丙米嗪治疗抑郁症对照分析

目的:观察文拉法辛与丙米嗪治疗抑郁症的疗效。方法:80例抑郁症患者随机分为两组,分别以文拉法辛及丙米嗪治疗。疗程6周。采用汉密尔顿抑郁量表(HAMD)、临床疗效总评量表疾病严重程度(CGI-SI)评定疗效,用副反应量表(TESS)观察不良反应。结果:文拉法辛组显效率80%,丙米嗪组75%,两组相仿。HAMD焦虑/躯体化因子分下降以文拉法辛组更为显著,文拉辛组不良反应较少,程度较轻,不需处理。结论:文拉法辛治疗抑郁症的疗效与丙米嗪相当,不良反应较少,依从性好。

Comparative analysis of depression treated with venlafaxine and imipramine respectively

Objective:To observe the efficacy of depression treated with venlafaxine and imipramine. Method:80 depressive patients were divided into venlafaxine group and imipramine group for 6 weeks respectively.Hamilton depressive scale (HAMD) and clinical global impression severity of illness (CGI-SI) were used to assess the efficaey,and treatment emergent symptom scale (TESS)was to observe the side effect. Results:Marked improvement rate of venlafaxine group was 80%,and imipramine group was 75%.The score of anxiety/somatie factor in HAMD was decreased more significantly in venlafaxine group.Side effects were less and milder in venlafaxine group,it was not necessary to be treated. Conclusion:The efficacy of depression treated with venlafaxine is as same as imigramine.Its side effects are less.Its compliance is good.