Cytomegalovirus retinitis secondary to chronic viremia in phagocytic leukocytes. |
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| Authors: | M Fiala S N Chatterjee S Carson S Poolsawat D C Heiner A Saxon L B Guze |
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| Affiliation: | Department of Medicine, Martin Luther King, Jr., General Hospital and Charles R. Drew Postgraduate Medical School, Los Angeles; University of California, Orange, California; Department of Urology, University of California, Davis, California; Department of Ophthalmology, University of Southern California School of Medicine, Los Angeles, California; Department of Pathology, University of Southern California School of Medicine, Los Angeles, California; Department of Pediatrics, Harbor General Hospital, Torrance, California; Department of Microbiology and Immunology, UCLA School of Medicine, Los Angeles, California; Research and Medical Service, Wadsworth Hospital Center, Los Angeles, California; Veterans Administration, Wadsworth Hospital Center, Los Angeles, California |
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| Abstract: | We studied the relationship between the duration and intensity of cytomegalovirus viremia, cytomegalovirus complement fixing antibody, and cytomegalovirus retinitis in 61 renal transplant recipients. Five (8%) patients had chronic viremia which lasted more than six months. Two of the five developed typical cytomegalovirus retinitis and a severe fungal infection after intensive viremia of more than 11 months' duration. Retinitis did not develop in 22 patients with short-term viremia. Infectious cytomegalovirus was largely associated with polymorphonuclear leukocytes, but the virus was associated with monocytes during the immature granulocytic response accompanying one patient's terminal illness. |
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