邻甲苯胺对小鼠的免疫毒性研究

用邻甲苯胺对小鼠亚急性染毒，观察对免疫功能影响。研究发现：脾脏是邻甲苯胺作用的一重要靶器官。免疫系统受到抑制，表现为１９ｍｇ／ｋｇ以上染毒引起脾脏增大，且呈剂量－反应关系；３８ｍｇ／ｋｇ以上引起白细胞计数和淋巴细胞比例升高，中性细胞比例下降；７６ｍｇ／ｋｇ引起Ｔ淋巴细胞百分比、抗体生成细胞和吞噬细胞吞噬功能下降。

Toxicity effect of O─toluidine on immune system in mice

The study found that spleen is an important target organ and the function of immune system is depressed.The spleen weight is increased with the amount of exposure above 19mg/kg body weight,which shows a dose-reaction relationship,White blood cell counts and lymphocyte percentage are increased,whereas neutrophil leukocyte percentage is decreased with the amount of exposure above 38mg/kg body weight.Lyphocyte percentage and the number of antibody forming cell and the phagocytosis of macrophage are decreased with the amount of exposure at 76mg/kg body weight.