脑深部电刺激治疗难治性癫癎

目的探讨脑深部电刺激（deep brain stimulation,DBS）在治疗难治性癫中的应用。方法回顾性分析接受DBS治疗的4例难治性癫病人的临床资料,1例选择丘脑前核电刺激,3例选择杏仁核-海马复合体电刺激。分析DBS治疗难治性癫的术前评估、手术方法及治疗效果。结果随访11-33个月,3例病人发作均减少50%以上,1例无效。结论对于不适合接受开颅切除性手术治疗的药物难治性癫病人,DBS治疗为安全而有效地治疗方式之一。靶点的选择主要依据癫癎样放电的部位及特点。

Treatment of intractable epilepsy by deep brain stimulation

Objective To investigate the application of deep brain stimulation （DBS） for intractable epilepsy. Methods Clinical data of 4 intractable epilepsy patients undergoing DBS were analyzed retrospectively. The stimulation targets were anterior nucleus of the thalamus （ANT） in 1 patient and amygdala-hippocampus complex （AH-C） in 3 patients. The preoperative evaluation, surgical techniques and outcome of DBS in the treatment of intractable epilepsy were analyzed. Results All the patients were followed-up for 11 to 33 months, seizures were reduced by more than 50% in 3 patients and invalid in 1. Conclusions For patients with intractable epilepsy who are not suitable for craniotomy surgery for resection, DBS is a safe,and effective treatment. Target choice is based mainly on the site and characteristics of epileptiform discharges.