| 表皮生长因子受体在鼻咽癌原发灶和颈部淋巴结转移灶间的表达差异 |
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| 引用本文： | 黄莹,卢泰祥,何洁华,罗容珍,林桐榆. 表皮生长因子受体在鼻咽癌原发灶和颈部淋巴结转移灶间的表达差异[J]. 南方医科大学学报, 2009, 29(5): 949 |
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| 作者姓名： | 黄莹 卢泰祥 何洁华 罗容珍 林桐榆 |
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| 作者单位： | 华南肿瘤学国家重点实验室,中山大学肿瘤防治中心,广东,广州,510060;华南肿瘤学国家重点实验室,放疗科,广东,广州,510060;华南肿瘤学国家重点实验室,中山大学肿瘤防治中心,广东,广州,510060;华南肿瘤学国家重点实验室,病理科,广东,广州,510060;华南肿瘤学国家重点实验室,中山大学肿瘤防治中心,广东,广州,510060;华南肿瘤学国家重点实验室,内科,广东,广州,510060 |
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| 摘 要： | 目的 探讨表皮生长因子受体(EGFR)在鼻咽癌原发灶和颈部淋巴结转移灶之间的表达差异及其临床意义.方法 应用免疫组化方法检测86例初治鼻咽癌患者的鼻咽原发灶和相应颈部淋巴结转移灶EGFR的表达情况.结果 EGFR在鼻咽癌原发灶和颈部淋巴结转移灶的阳性表达率分别为73.3%和60.5%(P=0.001);EGFR在原发灶和颈部淋巴结转移灶之间总的变化率为29.1%.结论 临床上对于鼻咽癌,尤其是局部晚期鼻咽癌进行EGFR靶向治疗时,应考虑EGFR在原发灶和转移灶的确切状况.
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| 关 键 词： | 鼻咽肿瘤 淋巴结转移 表皮生长因子受体 免疫组织化学 |
Expressions of epidermal growth factor receptor in primary nasopharygeal carcinoma and lymph node metastases |
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| HUANG Ying,LU Tai-xiang,HE Jie-hua,LUO Gong-zhen,LIN Tong-yu. Expressions of epidermal growth factor receptor in primary nasopharygeal carcinoma and lymph node metastases[J]. Journal of Southern Medical University, 2009, 29(5): 949 |
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| Authors: | HUANG Ying LU Tai-xiang HE Jie-hua LUO Gong-zhen LIN Tong-yu |
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| Affiliation: | HUANG Ying1,2,LU Tai-xiang1,HE Jie-hua1,4,LUO Rong-zhen1,LIN Tong-yu1,3 1State Key Laboratory of Oncology in South China,Departments of Radiation Oncology2,Radiation Oncology3 and Pathology4 of Cancer Center,Sun Yat-sen University,Guangzhou 510060,China |
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| Abstract: | Objective To investigate the expressions of epidermal growth factor receptor (EGFR) in primary nasopharygeal carcinoma (NPC) and lymph node metastases. Methods Archived samples of primary NPC and paired lymph node metastases from 86 patients were examined immuohistochemically for the protein expression of EGFR. Results EGFR expression positivity was detected in the primary NPC and lymph node metastases at the rate of 73.3% and 60.5%,respectively,and primary and metastatic foci showed significant difference ... |
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| Keywords: | nasopharyngeal neoplasms epidermal growth factor receptor lymph node metastases immunohistochemistry |
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