超微粉碎对当归中基本化学成分溶出的影响

目的比较不同粒径当归药材中阿魏酸及其他化学成分溶出的情况。方法采用高效液相色谱法分别对当归超微粉和40目、100目普通粉中所含化学成分进行定量、定性研究。结果以超声处理10min为条件，当归超微粉中的阿魏酸溶出量分别比40目、100目普通粉提高了82．51％和81．09％。在所含基本化学成分的图谱中，超微粉谱图的峰数较多，即溶出的物质较多，且在共有峰中超微粉的相对峰面积较大。结论超微粉碎能明显提高当归药材中化学成分溶出。

Effect of Ultra-fine Attrition on the Angelica Sinensis Radix Basic Chemical Dissolubility

OBJECTIVE Study on the influence of different grain sizes on the dissolution of the ferulic acid and other chemical composition. METHODS Ultra-fine, 40 mesh and 100 mesh powder of the Angelica Sinensis Radix were quantitatively and qualitatively studied by HPLC. RESULTS Comparing with 40 mesh and 100 mesh powder of Angelica Sinensis Radix treated with sonication for 10 min, the ferulic acid-soluble out rate of the ultra-fine powder were increased separately by 82.5% and 81.09%. Furthermore, the number of peaks in the HPLC graph of ultra-fine powder was more than that of 40 mesh and 100 mesh powder, which indicated that more chemicals in the Angelica Sinensis Radix were dissolved out. And also, the area of relative peaks of ultra-fine powder were larger than that of the traditional ones. CONCLUSION The technique of ultra-fine grinding can significantly improve the dissolution of the chemical constituents of Angelica Sinensis Radix.