胰岛素泵治疗2型糖尿病的临床研究

目的 观察胰岛素泵连续皮下胰岛素注射对2型糖尿病患者强化血糖控制的效果。方法 2型糖尿病患者26例，随机分成2组，CSII组12例，采用胰岛素泵连续皮下注射短效胰岛素。MSII组患者14例，采用多次胰岛素注射法，在每日三餐前注射短效胰岛素，并在每晚睡前加注中效胰岛素。结果 两组均能有效控制血糖达到较好的水平，CSII组需要的达标血糖时间，胰岛素用量及低血糖发生率明显减少。结论 胰岛素泵强化治疗能较好的模拟胰岛素分泌的生理节律，更有效地控制高血糖，减少血糖的波动和低血糖的发生。

Clinical study on treating type 2 diabetes with insulin pump

Objective To investigate the effect of intensive therapy of continuous subcutaneous insulin infusion (CSII) on type 2 diabetes patients. Methods 26 cases of type 2 diabetes were randomly divided into CSII group (12 cases) and multiple subcutaneous insulin injection (MSII) group (14 cases). The patients of CSII group short acting Novolin R was subcutaneous infused slowly by insulin pump continuously. In group of MSII, the short acting Novolin was subcutaneous injected before three meals a day and medium acting Novolin was injected before sleep at night. Results Hypergly cemia in the CSII and MSII were depressed. The time of blood glycose control was shorter in CSII group than that in MSII group, and the insulin administration dose in CSII group was lower than that in MSII group. The rate of hypoglycemia in CSII group was lower than that in MSII group. Conclusions The intensive treatment using insulin pump could imitate the secretion of physiological insulin, and control glycose level.