绝经后2型糖尿病女性骨质疏松与胱抑素C的关系

目的 探讨绝经后2型糖尿病女性骨质疏松(OP)与血清胱抑素C(cysC)的关系.方法 应用免疫放射比浊法测定cysC,并根据Coekcroft-Gault公式推算出的肾小球滤过率(GFR),85例绝经后2型糖尿病女性分为骨质疏松(OP)组与非骨质疏松(non-OP)组,比较尿素氮(BUN)、肌酐(Cr)、尿白蛋白/肌酐(ACR)、GFR等指标；将骨密度(BMD)与上述指标进行pearson相关分析；根据 GFR将85例患者从高到低分为三组,比较三组的骨密度及OP患病率.结果 OP组较non-OP组Cr、ACR高(P＜0.05或P＜0.01),GFR低(P＜0.01),BMD与GFR正相关.双侧股骨BMD (F=3.454,P＜0.05)及OP患病率(x2=9.435,P＜0.05)在不同GFR水平上的差异有统计学意义.结论 绝经后2型糖尿病女性可应用cysC的测定,及早发现肾功能的下降,以便对骨质疏松进行及早的预防和干预.

Relationship between osteoporosis and cystatin C in postmenopausal women with type 2 diabetes

Objective To investigate the relationship between osteoporosis and cystatin C in postmenopausal women with type 2 diabetes. Methods Cystatin C（cys C） was measured by immune scatter turbidimetry and glomerular fil- tration rate（GFRI was calculated by Cockeroft-Gault formula. 85 postmenopausal women with type 2 diabetes in hospital from April 2010 to July 2011 were divided into osteoporosis group and non-osteop0rosis group, and com- pared blood urea nitrogen { BUN }, creatinine { Cr }, Alb/creatinine （ACR）, GFR and so on between two groups. We made pearson correlation analysis between BMD and above mentioned indicators. 85patients were divided into three groups according to GFR from high to low degree, and compared BMD and osteoporosis morbidity among three groups. Results Cr and ACR were higher in OP group than non-OP group{ P〈0. 05 或 P〈0.01},GFR were lower in OP group than non-OP group（P〈0. 05 或 P〈0.01}. BMD and GFR were positive correlation. The difference was statistically significant in BMD Of two thighbones{ F= 3. 454, P〈0.05 } and osteoporosis morbidity（group A 34%, group B 69% ,group C 77% χ2= 9. 435, P〈0.05 ） among three groups. Conclusion Cys C measuration of postm- enopausal women with type 2 diabetes may detect the decrease of kidney function as soon as possible,prevent and treat osteoporosis as soon as possible.