| 早孕和足月滋养细胞中侵袭相关性基因的表达变化 |
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| 引用本文： | 黄莉萍,庞战军,邢福祺.早孕和足月滋养细胞中侵袭相关性基因的表达变化[J].细胞与分子免疫学杂志,2003,19(3):302-304. |
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| 作者姓名： | 黄莉萍 庞战军 邢福祺 |
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| 作者单位： | 第一军医大学南方医院妇产科,广东,广州,510515 |
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| 基金项目： | 国家重点基础研究发展规划 (973)资助 (No.G1 9990 5590 3) |
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| 摘 要： | 目的：探讨早孕和足月滋养细胞侵袭能力差异的机制。方法：分离并在体外培养早孕和足月的滋养细胞为，采用RT-PCR法，检测其侵袭相关性基因的表达。结果：早孕滋养细胞表达MMP-2、MMP-9、TIMP-1和UPA；而晚孕滋养细胞表达MMP-2、TIMP-1、TIMP-2和PAI。晚孕滋养细胞TTMP—1的表达显著高于早孕滋养细胞，而MMP-2的表达则无明显变化。结论：MMP-9等蛋白酶及其抑制因子表达的变化，可能是影响滋养细胞侵袭性的重要原因。
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| 关 键 词： | 早孕滋养细胞 足月滋养细胞 侵袭 |
| 文章编号： | 1007-8738(2003)03-302-03 |
| 修稿时间： | 2002年6月8日 |
Change in the expression of invasiveness-associated genes in early pregnancy and full-term trophocytes |
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| HUANG Li ping,PANG Zhan jun,XING Fu qi.Change in the expression of invasiveness-associated genes in early pregnancy and full-term trophocytes[J].Journal of Cellular and Molecular Immunology,2003,19(3):302-304. |
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| Authors: | HUANG Li ping PANG Zhan jun XING Fu qi |
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| Institution: | HUANG Li ping,PANG Zhan jun,XING Fu qi Department of Obstetrics and Gynecology,Nanfang Hospital,Guangzhou 510515,China |
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| Abstract: | AIM: To explore the mechanisms of invasiveness differences between early pregnancy and full term trophocytes. METHODS: The expression of invasiveness associated genes in early pregnancy and full term trophocytes cultured in vitro was investigated by RT PCR. RESULTS: It showed that early pregnancy trophocytes expressed matrix metalloproteinase(MMP 2, MMP 9), tissue inhibitor of metalloproteinase 1(TIMP 1) and urokinase plasmin activator(uPA). PAI and TIMP 2 were expressed in full turm trophocytes. Moreover, the expressed level of TIMP 1 in full term trophocytes was significantly higher than that in early pregnancy trophocytes. CONCLUSION: The change of MMPs and TIMPs expression may be involved in the different invasiveness between early pregnancy and full term trophocytes. |
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| Keywords: | early pregnancy full term trophocyte invasiveness |
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