| “双固一通”针法对绝经后骨质疏松症模型大鼠骨组织白细胞介素-6 mRNA表达水平的影响 |
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| 引用本文： | 鲍圣涌,王华,林婉娟,张少君,梁凤霞.“双固一通”针法对绝经后骨质疏松症模型大鼠骨组织白细胞介素-6 mRNA表达水平的影响[J].中华中医药杂志,2009(1). |
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| 作者姓名： | 鲍圣涌 王华 林婉娟 张少君 梁凤霞 |
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| 作者单位： | 暨南大学第二临床医学院附属深圳市人民医院;湖北中医学院; |
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| 基金项目： | 深圳市科技计划资助项目(No.医疗卫生类200702131) |
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| 摘 要： | 目的:探讨双固一通针法治疗绝经后骨质疏松症(PMO)的可能作用机制。方法:采用60只6月龄雌性SD大鼠,切除双侧卵巢后饲养90d,造成实验性骨质疏松症动物模型,然后随机分成对照组、常规取穴组、双固组、一通组、双固一通组5组,每组12只。对照组不做任何治疗;常规取穴组取背俞穴脾俞、胃俞、肾俞,气海俞;双固组取关元、足三里;一通组取肾俞、膈俞、大杼;双固一通组取关元、足三里、肾俞、膈俞、大杼。电针治疗每天1次,每次15min,留针10min,连续治疗6d后休息1d,连续治疗12周。利用RT-PCR技术检测IL-6 mRNA在骨组织细胞的分布。结果:与对照组比较,所有针刺组的IL-6 mRNA表达均减弱(P<0.05),双固一通组表达明显减弱(P<0.01);双固一通组较常规取穴组、双固组、一通组减弱(P<0.05);常规取穴组、双固组、一通组三组之间比较无显著性差异(P>0.05)。结论:针刺能够降低绝经后骨质疏松症模型大鼠骨组织的IL-6 mRNA表达水平,且双固一通针法优于其他三治疗组。
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| 关 键 词： | 绝经后骨质疏松症 针刺疗法 白细胞介素-6 去卵巢大鼠 实验研究 |
Effect of Shuanggu Yitong acupuncture therapy on interleukin-6 of experimental rats with postmenopausal osteoporosis |
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| Abstract: | Objective:To study the mechanisms that acupuncture therapy of Shuanggu Yitong in treating postmenopausal osteoporosis(PMO).Methods:60female SD rats aged 6 months were resected bilateral ovaries and feeded for 90 days in order to make the model of experimental osteoporosis.Then,they were divided into 5 groups such as control group,regular acupoints treated group,Shuanggu group,Yitong group,Shuanggu Yitong group,with 12 rats each group,and the control group without any treatment;Pishu(BL 20),Weishu(BL 21),She... |
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| Keywords: | Postmenopausal osteoporosis Shuanggu Yitong acupuncture therapy Interleukin-6 Rats without ovaries Experimental study |
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