甲状腺癌组织中CXCR4表达及临床病理意义

目的:研究甲状腺癌组织中CXCR4表达及临床病理意义。方法:51例甲状腺癌手术切除标本及20例结节性甲状腺组织切除标本常规制作石蜡包埋切片,染色方法为免疫组化SP染色法。结果:结节性甲状腺组织中未检测到CXCR4表达,甲状腺乳头状癌及未分化癌中表达率分别为26.3%和80.0%,颈部淋巴结未转移组与转移组表达率分别为28.6%和60.9%,差异均有显著性意义(P<0.05)。结论:甲状腺癌中CX-CR4是反应甲状腺癌进展、转移及预后的重要趋化因子受体。

Expression of CXCR4 in Thyroid cancer and Clinicopathological significance

Objective:To study the expression of chemokine receptor(CXCR4) in thyroid cancer and its clinicopathological significances.Methods: S-P immunohistochemical technique was used to test the expression of chemokine receptor(CXCR4) in 51 cases of thyroid cancer and 20 cases of nodular goiter.Results: Expression of CXCR4 in nodular goiter had not been detected.But the positive rates of CXCR4 respectively were 26.3% and 80.0% in human papillary thyroid carcinoma and undifferentiated thyroid carcinoma.The positive rates of CXCR4 respectively were 28.6% and 60.9% in those with cervical lymph node metastasis and in those without metastasis the differences were significant(P<0.05).Conclusion: Expression of CXCR4 can reflect the progression metastatic status and prognosis in thyroid cancer and has important clinicopathological significances.