T-cell depleted bone marrow transplantation for plasma cell myeloma |
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| Authors: | A. Ben Yehuda R. Or E. Naparstek S. Slavin A. Polliack |
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| Affiliation: | (1) Department of Internal Medicine A, Hadassah University Hospital and Hebrew University Hadassah Medical School, IL-91120 Jerusalem, Israel;(2) Department of Bone Marrow Transplantation, Hadassah University Hospital and Hebrew University Hadassah Medical School, IL-91120 Jerusalem, Israel;(3) Lymphoma Leukemia Unit, Department of Hematology, Hadassah University Hospital and Hebrew University Hadassah Medical School, IL-91120 Jerusalem, Israel |
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| Abstract: | Summary A 37-year-old male patient with advanced refractory plasma cell myeloma underwent T-cell depleted bone marrow transplantation (BMT) after 7 years of active disease previously treated with combination chemotherapy and irradiation. After the BMT there was marked clinical improvement and the patient is currently in good clinical condition two years after the BMT was performed. However, residual myeloma cells are still seen in the marrow and stable levels of paraprotein are still present in the serum. No GVHD was encountered after BMT. The problems of BMT in myeloma are discussed with a review of the current pertinent literature. |
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| Keywords: | T-cell depletion Bone marrow transplantation Multiple myeloma, plasma cells |
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