| 他克莫司基因组学在肝移植的应用及其研究进展 |
| |
| 引用本文： | 金昭,蔡卫民. 他克莫司基因组学在肝移植的应用及其研究进展[J]. 中国临床药理学杂志, 2008, 24(2): 165-168 |
| |
| 作者姓名： | 金昭 蔡卫民 |
| |
| 作者单位： | 上海交通大学,医学院,附属瑞金医院,药剂科,上海,200025 |
| |
| 摘 要： | 他克莫司是一种新型强效免疫抑制剂,在临床广泛应用于肝移植等器官移植术后的抗排异治疗。在肝移植人群中,他克莫司的药代动力学及血药浓度存在个体差异,其用药的个体差异与细胞色素P450酶系CYP3A5和P糖蛋白的基因多态性之间存在较密切联系。本文对他克莫司的药效学、药代动力学、血药浓度范围及其药物基因组学的研究进展进行了综述。
|
| 关 键 词： | 他克莫司 肝移植 基因多态性 |
| 文章编号： | 1001-6821(2008)02-0165-04 |
| 修稿时间： | 2007-04-24 |
Progress in pharmacogenomics of tacrolimus in liver transplantation |
| |
| JIN Zhao,CAI Wei-min. Progress in pharmacogenomics of tacrolimus in liver transplantation[J]. The Chinese Journal of Clinical Pharmacology, 2008, 24(2): 165-168 |
| |
| Authors: | JIN Zhao CAI Wei-min |
| |
| Abstract: | Tacrolimus,a novel macrocyclic lactone with potent immunosuppressive properties,is generally used in organ transplantation to prevent allograft rejection.There is a wide interindividual variation in pharmacokinetics and therapeutic window of tacrolimus in liver transplant recipients.Recently,many studies indicated that there is a close association between interindividual variation of tacrolimus and genetic polymorphism of CYP3A5 and MDR1.In this review,pharmacodynamics,pharmacokinetics,therapeutic window and pharmacogenomics of tacrolimus in liver transplantation are discussed. |
| |
| Keywords: | tacrolimus liver transplantation genetic polymorphism |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
