骨髓间充质干细胞移植对心衰大鼠心脏功能的影响

目的探讨骨髓间充质干细胞(MSCs)移植对心力衰竭大鼠心功能的影响。方法建立心衰大鼠模型,获取大鼠骨髓,随机分为两组:细胞移植组心肌内注射MSCs,培养液组心肌内注射细胞培养液,另取正常大鼠10只作为对照组。对3组大鼠移植前及移植后4周进行心功能测定。处死动物,心脏切片进行组织病理学检查。结果移植4周后,细胞移植组的心功能明显改善(P<0.05)。细胞移植组心肌组织内可见MSCs,与培养液组比较细胞移植组心肌纤维化明显改善。结论 MSCs移植可以改善心衰大鼠的心脏功能,其机制可能为改善心肌纤维化。

Effect of Bone Marrow Mesenchymal Stem Cell Transplantation on Myocardium Function in Rats

Objective To discuss the effect of bone marrow mesenchymal stem cell(MSCs) transplantation on myocardium function in rats.Methods Heart failure rat model were established.The rats were divided into two groups randomly and their bone marrow were acquired.In transplantation group,MSCs were injected into myocardium;in culture medium group,cell culture medium were injected into myocardium;another ten normal rats served as normal control group.Four weeks after transplantation,cardiac function was assessed again.Hearts were harvested and detected by histopathological method.Results After 4 weeks transplantation,heart functions were improved significantly in transplantation group(P<0.05).Compared with culture medium group,the symptom of myocardial fibrosis were improved significantly in transplantation group.Conclusion MSCs transplantation could change the myocardium function of rats with heart failure.Its mechanism possibly was MSCs improved the myocardial fibrosis.