左氧氟沙星治疗老年社区获得性肺炎临床观察

目的 了解左氧氟沙星治疗老年社区获得性肺炎(CAP)的临床有效性和不良反应的发生情况.方法 老年CAP患者36例,均应用左氧氟沙星治疗,每日1次0.5 g静脉滴注,疗程5～14 d.结果 22例痰培养检出多药耐药的肺炎链球菌,8例检出铜绿假单胞菌,6例检出流感嗜血杆菌,临床有效率为75.0%;细菌清除率为82.1%;相关腹泻、皮疹、肾损害各2例,占16.7%.结论 左氧氟沙星治疗老年CAP疗效好,不良反应发生率相对较低.

Clinical observation on levofloxacin for the treatment of community acquired pneumonia in elderly patients

Objective To observe the efficacy and safety of levofloxacin for the theatment of com-munity acquired pneumonia(CAP) in the elderly patients. Methods Thirty-six elderly inpatients with CAP between May 2005 and May 2007 were treated with levofloxacin at a dosage intravenously of 500 mg once a day for 5 to 14 days treatment. Results Streptococcus pneumoniae of multiple drugs-resistant were found in sputum of 22 patients,pseudomonas aeruginosa in 8 patients and haemophilus influenzae in 6 patients de-pending on the results of the sputum culture. The total clinical efficacy rate of levofloxacin was 75.0% and bacteria elimination rate was 82.1%,and 16.7% patients showed related side effect of diarrhea,skin-rash and kidney injury. Conclusions Levofloxacin is an effective with little side effect in treatment of CAP in the elderly.