| 无创性肢体缺血预适应的早期及延迟效应对中年大鼠心肌缺血再灌注损伤的保护作用和差异 |
| |
| 引用本文： | 宋二飞,陈敏,张轩萍,王微,刘飞君,梁月琴,张明升.无创性肢体缺血预适应的早期及延迟效应对中年大鼠心肌缺血再灌注损伤的保护作用和差异[J].中国药物与临床,2010,10(4):369-372. |
| |
| 作者姓名： | 宋二飞 陈敏 张轩萍 王微 刘飞君 梁月琴 张明升 |
| |
| 作者单位： | 1. 山西医科大学药理学教研室,太原,030001
2. 山西医科大学机能实验室,太原,030001 |
| |
| 基金项目： | 山西省自然科学基金，山西医科大学创新基金 |
| |
| 摘 要： | 目的研究无创性肢体缺血预适应的早期及延迟效应对中年大鼠心肌缺血再灌注(I/R)损伤的保护作用和差异。方法对预适应组中年大鼠实施1d或连续3d无创性后肢缺血预适应后,分别对其立即实施心脏I/R处理,或24h后再实施心脏I/R处理,与对照组(单纯实施心脏I/R)相比较,观察无创性肢体缺血预适应的早期和延迟效应对中年大鼠心脏I/R后心脏生理学指标心率(HR)、平均动脉压(MAP)、ST段]、血清学指标、心律失常Lambeth评分、各组I/R后的心肌梗死面积的影响。结果无创性后肢缺血预适应的早期效应组保护效应作用明显。1E,3E组心脏梗死面积(IS/AAR)减小,与对照组IS/AAR(50±9)%]比较,1E(15±5)%]和3E(35±10)%]组IS/AAR显著降低(P<0.05);心律失常Lambeth评分降低,1E(2.6±0.9)分]、3E(2.6±1.1)]分组与对照组(4.2±0.8)分]比较,差异有统计学意义(P<0.05);血清中丙二醛(MDA)的含量减少,血浆中MDA的含量在1E(7.4±1.2)nmol/ml]、3E(6.8±0.9)nmol/ml]组中较对照组大鼠(9.4±1.0)]nmol/ml均显著降低(P<0.05);超氧化物歧化酶(SOD)酶活性增加,血浆中SOD酶活性在1E(295±30)U/ml]、3E(345±22)U/ml]组中较对照组大鼠(257.4±21.0)U/ml]均显著升高(P<0.05,P<0.01);谷胱甘肽过氧化物酶(GSH-PX)酶活性增加,与对照组(1196±127)U/L]相比,早期预适应组1E(1547±193)U/L],3E(1624±69)U/L]组血清中GSH-PX的活性均显著增高(P<0.05)。结论无创性后肢缺血预适应的早期效应对中年大鼠心脏I/R损伤具有保护作用,且其作用大于其延迟效应。
|
| 关 键 词： | 大鼠 心肌再灌注损伤 适应 生理学 |
Protective effects against myocardial ischemia-reperfusion injury in middle-aged rats with early vs delayed noninvasive limb ischemic preconditioning |
| |
| SONG Er-fei,CHEN Min,ZHANG Xuan-pin,WANG Wei,LIU Feijun,LIANG Yue-qin,ZHANG Ming-sheng.Protective effects against myocardial ischemia-reperfusion injury in middle-aged rats with early vs delayed noninvasive limb ischemic preconditioning[J].Chinese Remedies & Clinics,2010,10(4):369-372. |
| |
| Authors: | SONG Er-fei CHEN Min ZHANG Xuan-pin WANG Wei LIU Feijun LIANG Yue-qin ZHANG Ming-sheng |
| |
| Institution: | SONG Er-fei*,CHEN Min,ZHANG Xuan-pin,WANG Wei,LIU Feijun,LIANG Yue-qin,ZHANG Ming-sheng.*Department of Pharmacology,Shanxi Medical University,Taiyuan 030001,China,030001,China. |
| |
| Abstract: | Objective To study the protective effects against myocardial ischemia-reperfusion (I/R) injury in middle-aged rats with early vs delayed noninvasive limb ischemic preconditioning.Methods Noninvasive ischemic preconditioning in right hind limb was given to middle-aged rats (preconditioned groups) for one and three days,respectively,followed by cardiac I/R immediately or after 24 hours.In comparison with the controls (non-preconditioned cardiac I/R treatment),the rats were studied for changes in cardiac physi... |
| |
| Keywords: | Rats Myocardial reperfusion injury Adaptation physiological |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
