肝硬化患者浆纤维蛋白原的水平及纤维蛋白单体聚合功能的研究

目的 :研究肝硬化患者血浆纤维蛋白原 (Fbg)水平及去肽A后纤维蛋白单体 (desA Afibrinmonomer)的聚合功能。方法 :以蕲蛇酶水解Fbg ,用计算机自动检测系统测定患者血浆中纤维蛋白单体聚合反应速率 (FMPS)、最大吸光度 (Amax)、凝固性纤维蛋白原含量 (FC)、反应延滞时间 (DT)、功能指标 (FI =FMPS/Amax)。结果 :失代偿性肝硬化患者 30例 ,其FMPS为 0 32 6± 0 0 6,Amax为 0 178± 0 0 2 8,FC为 1 70 0± 0 40 0g/L ,DT为 6± 2 0s ,FI为 1 831。除DT外其它数据均较对照组为低。结论 :失代偿性肝硬化患者因纤维蛋白原浓度下降致使纤维蛋白单体聚合功能降低 ,从而出现低凝状态 ,这可能是构成出血倾向的原因之一。

Study of Plasma Fibrinogen Level and Fibrin Monomer Polymerize Function in Patients with Hepatocirrhosis

Purpose: Study of plasma fibrinogen level and fibrin monomer after des A peptide polymerize function. Method: Acutulase hydrolyzed fibrinogen, and calculator automatic detection system were used for: fibrin monomer polymerization reaction speed(FMPS), maximum attraction luminosity (Amax), fibrinogen concentration (FC), reaction delayed time (DT), and function index (FI = FMPS/Amax). Results: Decompensation hepatocirrhosis 30 cases, its detection value: FMPS was 0.326 ± 0.06, Amax was 0.178±0.028, FC was 1.700 ± 0.400 g/L, DT was 6 ± 20 s, FI was1.831, except for DT they were lower than normal control group. Conclusion: Plasma Fbg concentration and fibrin monomer polymerize function were decrease, showed that patients were low coagulation state and contributing to one cause of hemorrhage.