| 苯骈吡喃肟类化合物的合成及生物活性 |
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| 引用本文： | 黄文龙,吴苏敏.苯骈吡喃肟类化合物的合成及生物活性[J].中国药科大学学报,1997,28(4):3-7. |
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| 作者姓名： | 黄文龙 吴苏敏 |
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| 作者单位： | 中国药科大学新药研究中心 |
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| 摘 要： | 苯骈吡喃类钾通道启开剂作为抗高血压药物正日益引人注目。根据现有构效关系，运用经典的药物设计方法，设计合成了２８个苯骈吡喃肟类化合物。初步药理研究表明，某些化合物有一定程度的扩血管活性。
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| 关 键 词： | 钾通道启开剂 苯骈吡喃 扩血管活性 合成 |
Synthesis and Bioactivity of Benzopyran 4 one Oximes |
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| Huang Wenlong,Wu Sumin,Yan Zheng,Peng Sixun Division of Medicinal Chemistry,China Pharmaceutical University,Nanjing.Synthesis and Bioactivity of Benzopyran 4 one Oximes[J].Journal of China Pharmaceutical University,1997,28(4):3-7. |
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| Authors: | Huang Wenlong Wu Sumin Yan Zheng Peng Sixun Division of Medicinal Chemistry China Pharmaceutical University Nanjing |
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| Institution: | Huang Wenlong,Wu Sumin,Yan Zheng,Peng Sixun Division of Medicinal Chemistry,China Pharmaceutical University,Nanjing 210009 |
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| Abstract: | Considerable attention is being given to the potassium channel openers of benzopyrans as potential therapeutical agents for hypertention Based on the structure activity relationships reported in the literatures and applying the classic theory of drug design, 28 benzopyran 4 one oximes were designed and synthesized Some of them exhibited the vasodilation activity |
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| Keywords: | Potassium channel openers Benzopyran Vasodilation Synthesis |
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