Risk factors for small bowel angioectasia: The impact of visceral fat accumulation |
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Authors: | Atsuo Yamada Ryota Niikura Yuka Kobayashi Hirobumi Suzuki Shuntaro Yoshida Hirotsugu Watabe Yutaka Yamaji Yoshihiro Hirata Kazuhiko Koike |
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Institution: | Atsuo Yamada, Ryota Niikura, Yuka Kobayashi, Hirobumi Suzuki, Shuntaro Yoshida, Hirotsugu Watabe, Yutaka Yamaji, Yoshihiro Hirata, Kazuhiko Koike, Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, JapanShuntaro Yoshida, Department of Endoscopy and Endoscopic Surgery, The University of Tokyo Hospital, Tokyo 113-8655, Japan |
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Abstract: | AIM: To investigate visceral fat accumulation in association with the risk of small bowel angioectasia.METHODS: We retrospectively investigated 198 consecutive patients who underwent both capsule endoscopy and CT for investigation of obscure gastrointestinal bleeding (OGIB) from January 2009 to September 2013. The visceral fat area (VFA) and subcutaneous fat area were measured by CT, and information on comorbidities, body mass index, and medications was obtained from their medical records. Logistic regression analysis was used to evaluate associations.RESULTS: Capsule endoscopy revealed small bowel angioectasia in 18/198 (9.1%) patients with OGIB. Compared to patients without small bowel angioectasia, those with small bowel angioectasia had a significantly higher VFA (96 ± 76.0 cm2
vs 63.4 ± 51.5 cm2, P = 0.016) and a higher prevalence of liver cirrhosis (61% vs 22%, P < 0.001). The proportion of patients with chronic renal failure was higher in patients with small bowel angioectasia (22% vs 9%, P = 0.11). There were no significant differences in subcutaneous fat area or waist circumference. The prevalence of small bowel angioectasia progressively increased according to the VFA. Multivariate analysis showed that the VFA odd ratio (OR) for each 10-cm2 increment = 1.1; 95% confidence interval (CI): 1.02-1.19; P = 0.021] and liver cirrhosis (OR = 6.1, 95%CI: 2.2-18.5; P < 0.001) were significant risk factors for small bowel angioectasia.CONCLUSION: VFA is positively associated with the prevalence of small bowel angioectasia, for which VFA and liver cirrhosis are independent risk factors in patients with OGIB. |
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Keywords: | Capsule endoscopy Obscure gastrointestinal bleeding Small bowel angioectasia Visceral fat accumulation |
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