一氧化氮与角质形成细胞凋亡的研究进展

一氧化氮(NO)是一种自由基,也是一种具有重要生理和病理功能的信使分子。广泛分布于生物体内各种组织之中,在皮肤、心、脑、肝和免疫调节等病理和生理过程中有着十分重要的生物学作用。近年来的研究显示NO能双向调节角质形成细胞(KC)的凋亡,对许多皮肤疾病的发生发展产生重要影响,然而该调节机制目前尚未完全阐明,本文将综述NO对KC凋亡的双向调节机制研究进展以及一些与NO调节失调相关的皮肤疾病。

Relationship of nitric oxide with the apoptosis of keratinocytes

Nitric oxide ~NO) is a kind of free radical, also is a signaling molecule, which universally distributed in the tissues of organism. NO play important role in the dermato-, cardia-, encephalo-, hepat- and immunological regulation on the physio- and patho- situation. Recently studying show that NO can bifunctionally regulate the apoptosis of keratinocytes, which play an important role in the occurrence and development of many skin diseases. However, the regulatory mechanism still can't be completely elucidated at present time. In this review, we are reviewing the recent investigation progress on the apoptosis of keratinocytes and some diseases of skin that related to the regulating disturbance of NO.