| 瘦素与结直肠癌的关系 |
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| 引用本文： | 王静雯,景洪标,郑金锋. 瘦素与结直肠癌的关系[J]. 国际病理科学与临床杂志, 2010, 30(1): 57-60. DOI: 10.3969/j.issn.1673-2588.2010.01.011 |
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| 作者姓名： | 王静雯 景洪标 郑金锋 |
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| 作者单位： | 济南军区总医院病理科,济南,250031;济南军区总医院病理科,济南,250031;济南军区总医院病理科,济南,250031 |
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| 摘 要： | 肥胖是结直肠癌发病的危险因素，瘦素是ob基因的表达产物，主要来源于脂肪细胞，是重要的脂肪因子之一，被认为是肥胖和结直肠癌之间联系的重要角色。近年来对瘦素在结直肠癌的形成和进展中的作用及机制的研究对结直肠癌的诊断和治疗具有重要意义。
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| 关 键 词： | 瘦素 结直肠癌 肥胖 |
Leptin and colorectal cancer |
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| WANG Jingwen,JING Hongbiao,ZHENG Jinfeng. Leptin and colorectal cancer[J]. Journal of International Pathology and Clinical Medicine, 2010, 30(1): 57-60. DOI: 10.3969/j.issn.1673-2588.2010.01.011 |
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| Authors: | WANG Jingwen JING Hongbiao ZHENG Jinfeng |
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| Affiliation: | WANG Jingwen,JING Hongbiao,ZHENG Jinfeng(Department of Pathology,Jinan Military Region General Hospital,Jinan 250031,China) |
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| Abstract: | Obesity is recognized as a high risk factor for colorectal cancer. As the ob gene product, leptin is one of important adipokines and it mainly derives from adipocytes. Leptin is thought as a pivotal link between obesity and colorectal cancer. It has been demonstrated to play a crucial role in colorectal carcinogenesis and cancer development. The progress made in the research on leptin is beneficial to colorectal diagnosis and therapy. |
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| Keywords: | leptin colorectal cancer obesity |
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