| MCP-1在难治性癫痫患者脑组织中的表达 |
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| 引用本文： | 吴原,王学峰,席志芹,肖飞,李劲梅,朱曦,孙纪军,龚云,刘风英,栾国明,王玉平,李云林,张建国,卢涌,李红卫. MCP-1在难治性癫痫患者脑组织中的表达[J]. 中国神经精神疾病杂志, 2006, 0(6) |
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| 作者姓名： | 吴原 王学峰 席志芹 肖飞 李劲梅 朱曦 孙纪军 龚云 刘风英 栾国明 王玉平 李云林 张建国 卢涌 李红卫 |
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| 作者单位： | 重庆医科大学附属第一医院神经内科重庆市神经病学重点实验室，重庆医科大学附属第一医院神经内科重庆市神经病学重点实验室，重庆医科大学附属第一医院神经内科重庆市神经病学重点实验室，重庆医科大学附属第一医院神经内科重庆市神经病学重点实验室，重庆医科大学附属第一医院神经内科重庆市神经病学重点实验室，重庆医科大学附属第一医院神经内科重庆市神经病学重点实验室，重庆医科大学附属第一医院神经内科重庆市神经病学重点实验室，重庆医科大学附属第一医院神经内科重庆市神经病学重点实验室，重庆医科大学附属第一医院神经内科重庆市神经病学重点实验室，首都医科大学天坛医院，首都医科大学宣武医院，首都医科大学宣武医院，首都医科大学天坛医院，重庆刑事科学研究所，重庆刑事科学研究所 重庆400016 广西医科大学附属第一医院神经内科，重庆 400016，重庆 400016，重庆 400016，重庆 400016，重庆 400016，重庆 400016，重庆 400016，重庆 400016 |
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| 基金项目： | 卫生部科学研究基金(98-1-354)，重庆市卫生局科研基金(编号:01-2-031)资助 |
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| 摘 要： | 目的了解难治性癫癎患者脑组织中单核细胞趋化蛋白-1(monocyte chemoattractant protein-1, MCP-1)的表达,探索其在难治性癫癎发病机制中的作用。方法在基因芯片扫描获阳性结果基础上,用免疫组织化学方法研究40例难治性癫癎患者脑组织中MCP-1的表达,并与对照组进行比较。结果基因芯片扫描显示MCP-1 mRNA表达上调,免疫组化结果进一步证实MCP-1在难治性癫癎患者脑组织中的表达较对照组明显增多(P<0．05)。结论MCP-1在难治性癫癎的发病机制中可能起着重要作用,阻断MCP-1有可能改变难治性癫癎的预后。
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| 关 键 词： | 难治性癫癎 单核细胞趋化蛋白-1 基因芯片 免疫组化 |
The expression of MCP-1 in brain tissue of patients with intractable epilepsy. |
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| WU Yuan,WANG Xue-feng,XI Zhi-qin,XIAO Fei,LI Jin-mei,ZHU Xi,SUN Ji-jun,GONG Yun,LIU Feng-ying,LUAN Guo-ming,WANG Yu-ping,LI Yun-lin,ZHANG Jian-guo,LU Yong,LI Hong-wei. Neurology. The expression of MCP-1 in brain tissue of patients with intractable epilepsy.[J]. Chinese Journal of Nervous and Mental Diseases, 2006, 0(6) |
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| Authors: | WU Yuan WANG Xue-feng XI Zhi-qin XIAO Fei LI Jin-mei ZHU Xi SUN Ji-jun GONG Yun LIU Feng-ying LUAN Guo-ming WANG Yu-ping LI Yun-lin ZHANG Jian-guo LU Yong LI Hong-wei. Neurology |
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| Affiliation: | WU Yuan,WANG Xue-feng,XI Zhi-qin,XIAO Fei,LI Jin-mei,ZHU Xi,SUN Ji-jun,GONG Yun,LIU Feng-ying,LUAN Guo-ming,WANG Yu-ping,LI Yun-lin,ZHANG Jian-guo,LU Yong,LI Hong-wei. Neurology Department of the First Affiliated Hospital,Chongqing Medi cal University,1 Youyi Road,Chongqing. 400016. |
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| Abstract: | Objective To investigate the expression and clinical signification of monocyte chemoattractant protein-1 ( MCP-1) in brain tissue of patients with intractable epilepsy, to learn the role of MCP-1 in the forming of intractable epilepsy. Methods 40 patients with intractable epilepsy were studied with cDNA microarray, and immunohistochemistry, and then MCP-1 expression was evaluated by immunohistochemistry, all results were compared with normal control. Results MCP-1 expression in brain tissue of patients with intractable epilepsy increased when they were compared with normal control, cDNA microarray showed MCP-1mRNA expression increasing (Ratio = 7. 171) , and immunohistochemistry result confirmed the results (p <0. 05) . Conclusions The increased expression of MCP-1 suggested that MCP-1 may play important role in the forming of intractable epilepsy, and block up MCP-1 may inhibited the forming of intractable epilepsy. |
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| Keywords: | Intractable epilepsy Monocyte chemoattractant protein-1 ( MCP-1) cDNA microarray Immumohistochemisry |
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