SOD免疫家兔组织中抗氧化酶及LPO的变化 |
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引用本文: | 曹文华!基础医学院生物化学与分子生物学教研室,李建伟!基础医学院生物化学与分子生物学教研室,陈文华,刘吉民!基础医学院生物化学与分子生物学教研室,杨翰仪!基础医学院生物化学与分子生物学教研室. SOD免疫家兔组织中抗氧化酶及LPO的变化[J]. 吉林大学学报(医学版), 1998, 0(5) |
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作者姓名: | 曹文华!基础医学院生物化学与分子生物学教研室 李建伟!基础医学院生物化学与分子生物学教研室 陈文华 刘吉民!基础医学院生物化学与分子生物学教研室 杨翰仪!基础医学院生物化学与分子生物学教研室 |
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作者单位: | 伊春市卫校生物化学教研室 |
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摘 要: | 目的 :研究外源性超氧化物歧化酶 (SOD)对机体的影响。方法 :测定 SOD免疫家兔组织中SOD、过氧化氢酶 (CAT)、谷胱甘肽过氧化物酶 (GSH- Px)及过氧化脂质 (LPO)的水平。结果 :与对照组相比 ,SOD免疫的家兔心、肾的 SOD活力 ,以及心、肾、肝的 GSH- Px活力明显下降 (P<0 .0 1 ) ;而心、肝、肾和脑的 LPO含量均明显增加 (P<0 .0 1 )。结论 :SOD免疫可能会影响机体的自由基代谢
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关 键 词: | 超氧化物歧化酶 免疫 抗氧化酶 过氧化脂质 自由基代谢 |
Changes of antioxidants status and LPO level in tissues of SOD immunized rabbits |
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Affiliation: | Department of Biochemistry & Molecular Biology |
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Abstract: | Objective:To investigate the effects of exogenous SOD on the bodies.Meathods:Home made purified SOD was used to immunize rabbits.When the titer of rabbit anti bovine SOD antibody was high,the level of SOD,CAT,GSH-Px,and LPO in the main tissue was measured.Results:Compared with the control,the activity of SOD in heart and kidney,the CAT activity in kidney,as well as the activity of GSH-Px in heart,kidney,and liver decreased markedly ( P <0 01).Meanwhile,the content of LPO in heart,liver,and brain increased ( P <0 01).Conclusion:It is implied that the SOD may have some effect on free radical metabolism after immunization. |
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Keywords: | superoxide dismutase (SOD) immunization antioxidant lipid peroxide (LPO) free radical metabolism |
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