早期应用纳络酮治疗急性重症脑出血临床观察

目的　观察早期应用纳络酮对急性重型脑出血预后的影响。方法　将 90例急性重症脑出血病人随机分为对照组 (n =45)和纳络酮组 (n =45)。观察治疗期间病人生命体征、颅内压和远期疗效 ,并进行统计学分析。结果　纳络酮组病人呼吸异常、心律异常明显减少 (P <0 0 1 ) ,清醒时间明显缩短 (P <0 0 1 )。 1周后颅内压显著升高者明显减少 (2 2 2 % ,P <0 0 1 ) ,3个月后治愈率明显增高 (61 8% ,P <0 0 1 )。结论　早期采用纳络酮治疗急性重症脑出血 ,可以降低颅内压 ,减轻脑水肿 ,缩短昏迷时间 ,促进神经功能恢复

The influence of naloxone used in early stage on acute severe intracerebral hemorrhage

Objective To study the effect of naloxone(NLX) used in early stage on acute severe intracerebral hemorrhage.Methods A retrospective review of 90 patients with acute severe intracerebral hemorrhage(45 cases were treated with NLX and 45 cases were control) was done on clinical data and neurological outcomes.Results The fluctuation of vital signs was smoother in NLX group than in control,including arrhythmia(14 versus 28,P<0.01) and abnormal respiration(11 versus 30,P<0.01).Lumbar puncture showed that the severity of brain edema and increase of intracranial pressure was less remarkable(10 versus 24,P<0.01) after treatemnt of NLX for one week.More patients revived in NLX group than in control(34 versus 13,P<0.01) and lower disability one after three months.Conclusion A successive large dosage of NLX can relieve acute severe intracerebral hemorrhage and improve the recovery of coma and reduce the disability in severe intracerebral hemorrhage.