| 静注Vit E乳剂对家兔心肌缺血再灌注期氧化应激的影响 |
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| 引用本文： | 赵学,杨宗才,李奇芬.静注Vit E乳剂对家兔心肌缺血再灌注期氧化应激的影响[J].中国药理学通报,1997(6). |
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| 作者姓名： | 赵学 杨宗才 李奇芬 |
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| 作者单位： | 第二军医大学长征医院心内科，第三军医大学西南医院 |
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| 摘 要： | 目的：探讨国产ＶｉｔＥ乳剂对家兔心肌缺血后再灌注期氧化应激的影响。方法：２０只家兔在急性心肌缺血３０ｍｉｎ后再灌注１２０ｍｉｎ。分别于再灌注前静脉注射国产ＶｉｔＥ１００ｍｇ·ｋｇ－１（ＶＥ组）和生理盐水对照乳剂（ＳＬ组）。结果：给药前、给药后５ｍｉｎ和１２０ｍｉｎ，ＶＥ组血浆ＶＥ浓度分别为０．０１±０．００２ｍｍｏｌ·Ｌ－１、０．２±０．０４ｍｍｏｌ·Ｌ－１和０．０９±０．０２ｍｍｏｌ·Ｌ－１。再灌注期血浆ＣｕＺｎ－ＳＯＤ和心肌Ｍｎ－ＳＯＤ活性升高，ＬＰＯ含量下降，心肌超微结构损伤减轻，收缩带坏死和梗塞范围均显著缩小。结论：国产ＶｉｔＥ乳剂能有效抑制氧化应激，对心肌再灌注损伤有较好保护作用。
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| 关 键 词： | VitE 心肌 再灌注损伤 |
Effects of native vitamin E emulsion on oxidative stress during myocardial ischemia reperfusion in rabbits |
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| Abstract: | AIM: To examine the effects of native vitamin E emulsion on oxidative stress associated with myocardial ischemia reperfusion. METHODS: 20 rabbits subjected to 30 min of acute myocardial ischemia and 120 min of reperfusion received intravenously native vitamin E emulsion 100 mg·kg-1 (VE group) and saline emulsion (SL group) respectively. RESULTS: Before, 5 min and 120 min after administration, VE levels in plasma were 001±0002 mmol·L-1, 02±004 mmol·L-1 and 009±002 mmol·L-1 respectively. Increased plasma CuZn SOD and myocardial tissue Mn SOD activities, decreased myocardial tissue lipidperoxide content, less injured myocardial ultramicroscopic structure, reduced size of contraction band necrosis and infarction were observed in VE group compared with SL group. CONCLUSION: The results suggest that the native vitamin E emulsion has an effective inhibition against oxidative stress and a better protection on myocardial reperfusion injuries. |
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| Keywords: | vitamin E myocardium reperfusion injury |
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